Rheumatoid Arthritis

Rheumatoid Arthritis: 3 (Current Directions in Autoimmunity)
by J.J. Goronzy (Editor), Cornelia M. Weyand (Editor)

Product details
* Hardcover: 282 pages
* Publisher: S Karger AG (23 Nov 2000)
* Language English
* ISBN-10: 3805571208
* ISBN-13: 978-3805571203

Book Info:
Rheumatoid arthritis is a crippling disease, affecting individuals in the prime of their life. This disease is emerging as a paradigm for complex autoimmune syndromes in which multiple genetic risk determinants in combination with non-inherited factors predispose individuals to generate chronically persistent and destructive immune responses. As a consequence of exploring the immunopathology of rheumatoid arthritis, biologic response modifiers have been introduced as a fundamental new therapeutic strategy for this clinically challenging disease. This book, the third volume of the new series "Current Directions in Autoimmunity", is the first one to exclusively focus on one disease. Written by experts in genetics and immunobiology, the articles reflect the complexity and multiple facets of the disease process but also show their convergence to a better understanding of pathogenetic mechanisms and the evolving clinical applications.

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Developmental Origins of Health and Disease

Developmental Origins of Health and Disease
by Peter D. Gluckman (Editor), M.A. Hanson (Editor)

Product details
* Hardcover: 542 pages
* Publisher: Cambridge University Press; 1st edition (20 April 2006)
* Language English
* ISBN-10: 0521847435
* ISBN-13: 978-0521847438

Book Info:
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis for this has begun to be studied in depth and fully understood. This compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances. The link between early development and the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis, also raises important public health issues. Another fascinating theme in the book concerns evolutionary developmental biology and how the 'evo-devo' debate can cast light on these concepts. Clinicians and scientists alike will all learn a lot about this exciting and emerging field.

• Links early development to the onset of many chronic diseases such as coronary heart disease, diabetes and osteoporosis
• Explains concepts, possible mechanisms, outcomes and public health consequences
• A definitive account of a rapidly emerging area
• Authors of the The Fetal Matrix: Evolution, Development and Disease

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