Clinical Neuroimmunology

Clinical Neuroimmunology
by Jack Antel (Editor), Gary Birnbaum (Editor), Hans-Peter Hartung (Editor), Angela Vincent (Editor)

Product Details:
* Hardcover: 464 pages
* Publisher: Oxford University Press, USA; 2 edition (November 10, 2005)
* Language: English
* ISBN-10: 0198510683

Book Description:

Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way.

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Decoding the Genomic Control of Immune Reactions

Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium (Novartis Foundation Symposia)
by Novartis Foundation (Author)

Product Details:
* Hardcover: 232 pages
* Publisher: Wiley (May 4, 2007)
* Language: English
* ISBN-10: 047002755X

Book Description
The immune system is one of the most complex systems in the body: Decoding the Genomic Control of Immune Reactions examines new strategies for exploiting the power of genomics to inform studies in immunology.
Part of the prestigious Novartis Foundation series, this title focuses on the new topic of ‘phenomics’, which is the use of genomic and bioinformatic techniques to characterize complex phenotypic systems, such as the immune system.
Contributors to this book explore existing strategies and examine possible new strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve outstanding problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but the bottleneck is to identify key sequences and circuits controlling the relevant immune reactions. This requires innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.
Some of the specific problems addressed are:
1. What kinds of information are we missing to understand how the genome sequence specifies the differentiation and response of immune system cells and system behaviour, such as immunological memory and tolerance?
2. Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues?
3. Which host and pathogen genome sequences and cellular circuits explain the failure of neutralizing immune responses to sophisticated human pathogens, such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses?
This book is an invaluable resource for researchers in both industry and academia performing either basic or clinical research in the disciplines of genomics and bioinformatics, immunology, microbiology and virology, cell and molecular biology, biotechnology, and genetics.

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