Viral proteases and Antiviral Protease Inhibitor Therapy: Proteases in Biology and Disease

Viral proteases and Antiviral Protease Inhibitor Therapy: Proteases in Biology and Disease
by: Uwe Lendeckel, Nigel M. Hooper

Product Details
* Hardcover: 370 pages
* Publisher: Springer; 1 edition (August 1, 2009)
* Language: English
* ISBN-10: 904812347X

Book Description
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads.
The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases:
* AIDS
* SARS
* Hepatitis
* Cytomegalovirus
* T-cell lymphotropic virus
* Picornavirus
This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.

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Diphtheria

Diphtheria (Deadly Diseases and Epidemics)
by: Patrick, Ph.D. Guilfoile

Product Details
* Library Binding: 120 pages
* Publisher: Chelsea House Publications; 1 edition (March 30, 2009)
* Language: English
* ISBN-10: 1604132280

Book Description
Although the earliest accounts of diphtheria date back at least 2,000 years, this disease was first associated with major epidemics in Europe during the 16th century. By the 18th century, diphtheria became a major cause of childhood illness and death in the New World. With the advent of widespread vaccination in the 1920s, the number of cases and deaths dropped dramatically. However, in areas where vaccination rates drop, diphtheria can rapidly become reestablished, as seen in the late 1990s in several former Soviet republics. Diphtheria is a bacterial infection caused by Corynebacterium diphtheriae, which attacks the respiratory system. "Diphtheria" describes the disease, the bacteria that causes it, and the development of effective treatments. Chapters of this title include: History of Diphtheria; How Does Corynebacterium Diphtheriae Cause Disease; How Is Diphtheria Treated; How Is Diphtheria Prevented; Resurgence of Diphtheria in the Former Soviet Union; and, Uses of Diphtheria Toxin.

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