Plasmids for Therapy and Vaccination

Plasmids for Therapy and Vaccination
By Martin Schleef

Product Details
* Hardcover: 320 pages
* Publisher: Wiley-VCH; 1 edition (February 13, 2001)
* Language: English
* ISBN-10: 3527302697

Book Description
This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.

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How the Immune System Recognizes Self and Nonself

How the Immune System Recognizes Self and Nonself: Immunoreceptors and Their Signaling
by Daisuke Kitamura

Product Details
* Hardcover: 251 pages
* Publisher: Springer; 1 edition (February 15, 2008)
* Language: English
* ISBN-10: 4431738835

Book Description

The immune system is a highly evolved security system that protects the body from infection by pathogens such as viruses and bacteria. The immune system also recognizes and rejects a transplanted organ from even the same species. Indeed, the immune system potentially recognizes and eliminates everything that invades the body (nonself). However, it does not normally eliminate self cells or tissues except tumor cells developed from self tissue. Occasionally the immune system breaks down and attacks the body components of the self, manifesting as autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, myasthenia gravis, and insulin-resistant diabetes. This book contains extensive updated reviews describing what kinds of receptors various immune cells use, how they recognize the self and the nonself components (and neoself such as tumors), and how finally the immune system distinguishes the self and nonself - a far more complicated process than a computer security system detecting infected documents. Perfect understanding of this system should make it possible in the future to regulate immunity to transplants, to cure autoimmune disease and allergy, and to facilitate tumor immunity.

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