What's Wrong With My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice

What's Wrong With My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice
by Jacqueline N., PhD Crawley (Author)

Product Details
* Hardcover: 523 pages
* Publisher: Wiley-Liss; 2 edition (March 23, 2007)
* Language: English
* ISBN-10: 0471471925

Book Description
Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse?
Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters:
"Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis.
"Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions.
The final chapter, "The Next Generation," examines new and emerging technologies.
Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

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Biologic Markers in Immunotoxicology

Biologic Markers in Immunotoxicology
by Subcommittee on Immunotoxicology, Committee on Biologic Markers, Board on Environmental Studies and

The Committee on Biologic Markers was organized to consider the areas of environmental research in which the use of biologic markers offered the greatest potential for major contributions. Four biologic systems were chosen: the reproductive system, the respiratory system, the immune system, and the urinary system. A companion report, report is the product of the Subcommittee on Immunotoxicology, which included clinicians, epidemiologists,
toxicologists, pathologists, and biochemists. Our intent was to consider various kinds of basic research that might reveal markers of environmental exposure and disease, even if the original goal of the research had nothing to do with such markers. Eventually, the subcommittee decided to place major emphasis on biologic markers of three types: markers originating from the immune system, markers related to immunosuppressive toxicants of exposure, and markers of effects of environmental pollutants. Markers of susceptibility to
environmental materials also were considered important and were included especially if they were of a genetic nature and could serve to identify individuals who are susceptible to autoimmune diseases.

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The Diatoms

The Diatoms
by E. F. Stoermer (Editor), John P. Smol (Editor)

Product Details
* Paperback: 482 pages
* Publisher: Cambridge University Press; 1st edition (August 15, 2001)
* Language: English
* ISBN-10: 0521004128

Book Description
Diatoms are microscopic algae which are found in virtually every habitat where water is present. This volume is an up-to-date summary of the expanding field of their uses in environmental and earth sciences. Their abundance and wide distribution, and their well-preserved glass-like walls make them ideal tools for a wide range of applications as both fossils and living organisms. Examples of their wide range of applications include environmental indicators, oil exploration, and forensic examination. The major emphasis is on their use in analyzing ecological problems such as climate change, acidification, and eutrophication. The contributors to the volume are leading researchers in their fields and are brought together for the first time to give a timely synopsis of a dynamic and important area. This book should be read by environmental scientists, phycologists, limnologists, ecologists and palaeoecologists, oceanographers, archaeologists and forensic scientists.

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Insect Immunology

Insect Immunology
by Nancy E. Beckage (Editor)

Product Details
* Hardcover: 384 pages
* Publisher: Academic Press; 1 edition (December 14, 2007)
* Language: English
* ISBN-10: 0123739764

Book Description
Given the critical importance of insect immunology in insect vector-parasite interactions and vector control, biological control of agricultural insect pests, and other key areas of entomological research and practice, a new comprehensive work summarizing recent breakthroughs in this rapidly expanding field is sorely needed. This work will constitute the first book-length publication on the topic of insect immunology since 1991, complimenting earlier works by offering a fresh perspective on current research. Interactions of host immune systems with both parasites and pathogens will be presented as well as the genomics and proteomics approaches which have been lacking in other publication.

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Phagocytosis of Bacteria and Bacterial Pathogenicity

Phagocytosis of Bacteria and Bacterial Pathogenicity (Advances in Molecular and Cellular Microbiology)
by Joel D. Ernst (Editor), Olle Stendahl (Editor)

Product Details
* Hardcover: 296 pages
* Publisher: Cambridge University Press; 1 edition (September 25, 2006)
* Language: English
* ISBN-10: 0521845696

Book Description
This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.

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