Regulatory T Cells in Inflammation

Regulatory T Cells in Inflammation (Progress in Inflammation Research)
by Leonie S. Taams (Editor), Arne N. Akbar (Editor), Marca H.M. Wauben (Editor)

Product Details:
* Hardcover: 240 pages
* Publisher: Birkhäuser Basel; 1 edition (May 31, 2005)
* Language: English
* ISBN-10: 3764370882

Book Description
Scientific interest in regulatory T cells has revived during the last decade. Initially described in the early seventies as suppressor T cells, the concept of suppressor/regulatory T cells went through turbulent times during the eighties when molecular analysis failed to identify putative suppressor genes. The constructive and elegant cellular experiments on regulatory T cells during the nineties, initiated by Shimon Sakaguchi and co-workers, however have brought these cells back into the limelight. Nowadays, regulatory T cells are regarded as essential components of the immune system, and several different subsets of regulatory T cells have been described. Considerable regulatory function has been attributed to the CD4+CD25+ T cell subset. These cells act by suppressing adaptive and possibly also innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T cells are cell-contact dependent but a role for soluble factors, particularly in vivo, has been suggested as well.
The aim of this book is to bring together recent developments and viewpoints in the field of CD4+CD25+ regulatory T cells and to discuss the potential use of regulatory T cells in immunotherapy of inflammatory diseases. By linking data on regulatory T cells from experimental models with recent findings from the clinic, this topical book will be of interest to immunologists and other biomedical researchers as well as clinicians that are interested in regulation and manipulation of the immune response during (chronic) inflammatory disease.

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Malaria Methods and Protocols

Malaria Methods and Protocols (Methods in Molecular Medicine)
by Denise L. Doolan (Editor)

Product Details:
* Hardcover: 648 pages
* Publisher: Humana Press; 1 edition (July 2002)
* Language: English
* ISBN-10: 0896038238

Book Description
Internationally respected scientists and clinicians describe in step-by-step detail their most useful conventional and cutting-edge techniques for the study of malaria. Areas covered include clinical and laboratory diagnosis and typing, animal models, molecular biology, immunology, cell biology, vaccinology, laboratory models, and field applications. Each readily reproducible protocol has been tested, standardized, and optimized for experimental success, and includes many laboratory notes on troubleshooting, avoiding pitfalls, and interpreting results. Several of the most widely used methods are described here in detail for the first time or have been thoroughly updated since their original publication (e.g., in vitro culture of Plasmodium parasites and in vitro growth inhibition assay).

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Cystic Fibrosis: Methods and Protocols

Cystic Fibrosis: Methods and Protocols (Methods in Molecular Medicine)
by William R. Skach (Editor)

Product Details:
* Hardcover: 608 pages
* Publisher: Humana Press; 1 edition (March 2002)
* Language: English
* ISBN-10: 0896038971

Book Description
Cystic Fibrosis: Methods and Protocols consolidates cutting-edge in vitro, cellular, and whole animal laboratory protocols into an indispensable resource. From electrophysiology and cell biology, to animal models and gene therapy, this comprehensive set of methods provides the step-by-step instructions needed for investigators to incorporate new approaches into their research programs. Specific protocols describe new techniques for diagnosis, in vitro methods for the expression and functional analysis of CFTR, novel biochemical and cellular systems to determine how mutations subvert CFTR function, and in vivo protocols to examine how CFTR dysfunction produce multisystem pathology in both human and animal models.

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