The Immune Synapse as a Novel Target for Therapy

The Immune Synapse as a Novel Target for Therapy (Progress in Inflammation Research)
By Luis Graca

Product Details
* Hardcover: 192 pages
* Publisher: Birkhäuser Basel; 1 edition (December 10, 2007)
* Language: English
* ISBN-10: 3764382953

Book Description
The immune synapse can be compared to a molecular machine that controls T cell activation when getting in contact with an antigen-presenting cell (APC). The immune synapse is involved in the transfer of information across the T cell-APC junction. It plays an essential role in the control and nature of the immune response. In recent years several approaches have been developed to reprogramming the immune response by targeting molecules involved in the immune synapse. Monoclonal antibodies, such as the ones targeting the lymphocyte co-receptor, co-stimulatory and adhesion molecules (CD3, CD4, CD40L, CTLA4-Ig, ICAM-1), or altered peptide ligands have been shown capable of inducing immune tolerance in transplantation, autoimmunity and allergy. This volume gives an overview on the progress in the field, from basic science to clinical trials, and the major mechanisms involved. It discusses how interfering with T cell activation may lead to immune tolerance, immune modulation and the recruitment of regulatory T cells, the role of monoclonal antibodies in tolerance induction, and mechanisms maintaining dominant tolerance. The book is of interest to clinicians and researchers working in this area.

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Biological Control of Crop Diseases

Biological Control of Crop Diseases (Books in Soils, Plant and the Environment)
by Samuel S. Gnanamanickam (Editor)

Product Details
* Hardcover: 480 pages
* Publisher: CRC; 1st edition (April 3, 2002)
* Language: English
* ISBN-10: 0824706935

Book Description
With contributions from more than 30 internationally renowned experts, this book combines coverage of theory with coverage of global practices. Highlighting the day-to-day challenges of organic crop management for cost-effective real-world application, the book explores the biological control of diseases in 12 major crops. It focuses on the use of host plant resistance through transgenics and induced systemic resistance as a part of biological control. Topics covered include the role of biocontrol agents for signaling resistance, effective ecofriendly alternative to combat bacterial, fungal, and viral infestation, and transgenic crops in disease management.

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