Mycobacterium tuberculosis Protocols

Mycobacterium Tuberculosis Protocols (Methods in Molecular Medicine)
by Tanya Parish (Editor), Neil G. Stoker (Editor)

Product Details:
* Hardcover: 424 pages
* Publisher: Humana Press; 1 edition (February 15, 2001)
* Language: English
* ISBN-10: 0896037762

Book Description
Leading investigators with extensive practical knowledge and experience describe their best methods for studying the tuberculosis pathogen. Packed with step-by-step instructions to ensure successful results, these methods range from basic handling techniques to the application of functional genomics. Highlights include methods for the basic safety and culture of M. tuberculosis, fractionation of the bacterium (nucleic acids, lipids, culture filtrate, and capsule), the analysis of gene expression (start site mapping, real-time PCR microarrays, and proteomics), the growth of the bacterium in macrophages and low oxygen, cytological analysis of the bacteria, and diagnostics. Highly practical and accessible, Mycobacterium tuberculosis Protocols utilizes advanced functional genomics and mutagenesis methodologies to provide both experimental and clinical investigators all the powerful techniques needed to illuminate the molecular biology of tuberculosis and its interactions with host cells, and so drive work on the wide variety of emerging therapeutic opportunities.

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Microbial DNA and Host Immunity

Microbial DNA and Host Immunity
by Eyal, Ed. Raz (Author)

Product Details:
* Hardcover: 408 pages
* Publisher: Humana Press; 1st edition (June 15, 2002)
* Language: English
* ISBN-10: 1588290220

Book Description
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

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