Modulation of Host Gene Expression and Innate Immunity by Viruses

Modulation of Host Gene Expression and Innate Immunity by Viruses
by Peter Palese (Editor), Jean-Pierre Changeux (Editor)

Product Details:
* Hardcover: 304 pages
* Publisher: Springer; 1 edition (March 8, 2005)
* Language: English
* ISBN-10: 1402032412

Book Description
This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents. Ulrich Desselberger, Gif-sur-Yvette/Cambridge.
Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases. Pharmaceutical industry professionals will also find interest in this illuminating look into virus/host interactions.

Download

Immunotherapy in 2020: Visions and Trends for Targeting Inflammatory Disease

Immunotherapy in 2020: Visions and Trends for Targeting Inflammatory Disease (Ernst Schering Foundation Symposium Proceedings)
by Andreas Radbruch (Editor), Hans-Dieter Volk (Editor), Khusru Asadullah (Editor), Wolf-Dietrich Döcke (Editor)

Product Details:
* Hardcover: 121 pages
* Publisher: Springer; 1 edition (August 2007)
* Language: English
* ISBN-10: 3540708502

Book Description
This volume features contributions from participants of the ESRF symposium on "Immunotherapy in 2020—Visions and Trends for Targeting Inflammatory Diseases" held in Potsdam near Berlin, Germany, in October 2006.
The symposium presentations covered the main mechanisms of immunoregulation such as peripheral and central tolerance, epigenetic programming, immunologic memory, and regulatory networks in inflammation as well as novel experimental and clinical approaches for targeting inflammation in autoimmunity and transplantation. An important related question is how recent findings in immunological research can lead to improved diagnostics, new drugs, and better therapies. The targeting of novel pathways and immunoregulatory mechanisms, the challenge of immunologic memory for lastingly successful anti-inflammatory therapy, new approaches for adoptive T cell and polyclonal antibody therapies, and the individualization of immunomodulatory therapies are thereby topics of this volume.

Download