Proteases of Infectious Agents

Proteases of Infectious Agents
by Ben Dunn (Editor)

Product Details
Hardcover: 282 pages
Publisher: Academic Press; 1st edition (June 15, 1999)
Language: English
ISBN-10: 0124205100

Book Description
Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.
Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area.
Key Features
* Includes information on the basic biology and function of proteases
* Provides global survey of current research efforts in protease inhibitors
* Illustrates how structure-based drug design targets effective and selective compounds
* Highlights important diseases that provide economically important targets
* Describes the role of proteases as important new targets for drug discovery

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Antimicrobial Resistance and Implications for the 21st Century

Antimicrobial Resistance and Implications for the 21st Century (Emerging Infectious Diseases of the 21st Century)
by I.W. Fong (Editor), Karl Drlica (Editor)

Product Details
Hardcover: 408 pages
Publisher: Springer; 1 edition (October 24, 2007)
Language: English
ISBN-10: 0387724176

Book Description
Antimicrobial resistance can develop in any type of microbe (germ). Microbes can develop resistance to specific medicines. A common misconception is that a persons body becomes resistant to specific drugs. However, it is microbes, not people that become resistant to the drugs. Drug resistance happens when microbes develop ways to survive the use of medicines meant to kill or weaken them. If a microbe is resistant to many drugs, treating the infections it causes can become difficult or even impossible. Someone with an infection that is resistant to a certain medicine can pass that resistant infection to another person. In this way, a hard-to-treat illness can be spread from person to person. In some cases, the illness can lead to serious disability or even death.
This comprehensive, up-to-date volume aims to define issues and potential solutions to the challenges of antimicrobial resistance. The chapter authors are leading international experts on antimicrobial resistance among a variety of bacteria (Streptococcus pneumoniae, enteroccoci, staphylococci, gram-negative bacilli, mycobacteria species) viruses (HIV, herpesviruses), parasites (malaria, leishmaniasis) and fungi (Candida species, fusarium etc.). The chapters will explore the molecular mechanisms of drug resistance, the immunology and epidemiology of resistance strains, clinical implications and implications on research and lack thereof, and prevention and future directions. This volume will also describe the steps that researchers are taking to develop molecular methods for detecting resistance; develop drugs and other means to deal with newly-resistant organisms. A special chapter to address the issues on strategies to limit antimicrobial resistance propagation will be included in this volume.

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