Bacterial Pathogenesis: Methods and Protocols

Bacterial Pathogenesis: Methods and Protocols (Methods in Molecular Biology)
by Frank DeLeo (Editor), Michael Otto (Editor)

Product Details
Hardcover: 414 pages
Publisher: Humana Press; 1 edition (January 31, 2008)
Language: English
ISBN-10: 1588297403

Book Description
Bacterial infections affect world health today as a leading cause of morbidity and mortality. Pathogenic bacteria routinely command a broad spectrum of niches in the human host, making an understanding of pathogenesis mechanisms crucial to the development of prophylactics and treatment for bacterial diseases. A variety of in vitro methods, in vivo animal model systems and cutting-edge genomics assays have arisen in the effort to study bacterial pathogenesis and identify potential therapeutic targets. In Bacterial Pathogenesis, in-depth methods and state-of-the-art protocols are presented for investigating specific mechanisms of pathogenesis for a wide range of bacteria. This invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections. Up-to-date molecular typing methods for Staphylococcus aureus and a new model of streptococcal pharyngitis in non-human primates are also included. Bacterial Pathogenesis will prove an invaluable collection for microbiologists, immunologists, cell biologists and infectious disease clinicians - and indispensable to all science researchers interested in studying pathogenic bacteria and related disease processes.

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The Third Domain - The Untold Story of Archaea

The Third Domain
by Tim Friend (Author)

Product Details
Hardcover: 312 pages
Publisher: Joseph Henry Press; 1 edition (July 12, 2007)
Language: English
ISBN-10: 0309102375

Book Description
The Third Domain is the untold story of how the discovery of a new form of life--one ignored for the past thirty years by mainstream scientists--is revolutionizing science, industry, and even our search for the existence of life beyond Earth.
For most of the history of science, people have been taught that the tree of life consists of two branches--one represented by bacteria and the other by all of the multi-celled organisms, including plants and animals. Few people realize that there is a third branch on that tree, or a third domain of life.
The scientific community was, therefore, shocked when in 1977, a lone scientist named Carl Woese determined that the archaea - biochemically and genetically unique organisms that live and thrive in some of the most inhospitable environments on Earth - were a distinct form of life, unlike anything seen on Earth before. It was an astonishing discovery. Initially labeled as an unimportant and novel form of bacteria, today key leaders of the scientific community are calling the archaea one of the most important scientific revelations of the 20th century.
The Third Domain tells the story of their strange potential - maverick entrepreneur Craig Venter now believes that the archaea holds critical importance to the biotech industry - and investigates their incredible history - many believe that they are the oldest form of life on Earth - to provide a riveting account of an astonishing discovery.

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