Fundamental Immunology

Fundamental Immunology, 6th Edition
By William E Paul

Product Details
* Hardcover: 1584 pages
* Publisher: Lippincott Williams & Wilkins; 6 edition (May 1, 2008)
* Language: English
* ISBN-10: 0781765196

Book Description
The textbook that has defined the field of immunology since 1984 is now in its thoroughly revised and updated Sixth Edition. This comprehensive, up-to-date text will be of interest to graduate students,post-doctoral fellows, basic and clinical immunologists, microbiologists and infectious disease physicians, and any physician treating diseases in which immunologic mechanisms play a role. This edition features expanded coverage of regulatory T cells, innate immunity, and dendritic cells. Additional chapters on cytokines are also included. A companion Website offers the fully searchable text, plus all illustrations in full color and comprehensive lists of references.

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Nucleic Acids in Innate Immunity

Nucleic Acids in Innate Immunity
By Ken J. Ishii, Shizuo Akira

Product Details
* Hardcover: 304 pages
* Publisher: CRC (May 22, 2008)
* Language: English
* ISBN-10: 1420068253

Book Description
Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system. Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.
The second section focuses on the therapeutic applicationsof immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.
The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation. Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

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Malaria: Genetic and Evolutionary Aspects

Malaria: Genetic and Evolutionary Aspects (Emerging Infectious Diseases of the 21st Century)
By Krishna R. Dronamraju, Paolo Arese

Product Details
* Hardcover: 190 pages
* Publisher: Springer; 1 edition (December 14, 2005)
* Language: English
* ISBN-10: 0387282947

Book Description
This book is an edited collection of papers by leading experts on the population genetics and evolutionary biology of malaria, a disease which results in three million deaths each year in the world. "Malaria Hypothesis" refers to the hypothesis, which was proposed by J.B.S. Haldane at the 8th International Congress of Genetics in Stockholm in 1948, that the identical eographic distribution of both falciparum malaria and thalassemia in the mediterranean region suggests that the heterozygous individuals for thalassemia (or microcythemia as it was called then) might have greater resistance to malarial infection. Haldane, later in the same year, expanded his theory to infectious disease in general at another international conference, at Pallanza in Italy. Haldane's hypothesis was subsequently confirmed in the African populations by A.C. Allison and later by others during the last fifty years, although at first for sickle cell anemia and later for thalassemia with varying degrees of success. The malaria hypothesis still remains today a unique example of that kind of balanced polymorphism, not only in genetics but in all of biology. It opened up new insights into our perspective of the genetics and population dynamics of disease prevalence, particularly infectious disease.

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