Antiviral Strategies

Antiviral Strategies (Handbook of Experimental Pharmacology 189)
By Hans-Georg Kräusslich, Ralf Bartenschlager

Product Details
* Hardcover: 379 pages
* Publisher: Springer; 1 edition (January 1, 2009)
* Language: English
* ISBN-10: 3540790853

Book Description
A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

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SARS- and Other Coronaviruses: Laboratory Protocols

SARS- and Other Coronaviruses: Laboratory Protocols (Methods in Molecular Biology 454)
By Dave Cavanagh

Product Details
* Hardcover: 344 pages
* Publisher: Humana Press; 1 edition (September 2, 2008)
* Language: English
* ISBN-10: 1588298671

Book Description
In 2003, the word “coronavirus” spread across the globe, somewhat further than the virus that sparked the panic. In SARS- and Other Coronaviruses: Laboratory Protocols, expert researchers examine these devastating viruses through detailed laboratory protocols. Chapters deal with such subjects as detection and discovery of coronaviruses by nucleic acid and antibody-based approaches, virus isolation, propagation and titration, virus purification, structure analysis by electron cryomicroscopy, expression and crystallization of viral proteins, raising antibodies against viral proteins, manipulation of the coronavirus genome, and descriptions of how to investigate aspects of the cell surface for coronavirus receptors.
Comprehensive and cutting-edge, SARS- and Other Coronaviruses Laboratory Protocols serves as an ideal guide for all virologists and especially for those working with coronaviruses.

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