The Macrophage

The Macrophage
by Bernard Burke (Editor), Claire E. Lewis (Editor)

Product Details
* Hardcover: 680 pages
* Publisher: Oxford University Press, USA; 2 edition (August 15, 2002)
* Language: English
* ISBN-10: 0192631977

Book Description
The field of macrophage research has grown enormously since publication of the first edition of this book. The Macrophage 2e provides a unique comprehensive review of the current scientific knowledge of the multifaceted role of this important and intriguiging cell in health and disease. In 16
chapters by experts in the field it covers the basic biology and diverse functions of macrophages in specific diseases and the complex of interactions between macrophages and other cells. Ranging from their role in the defense against pathogens, their role as hosts for pathogens (including HIV),
their complex roles in diseases such as arthritis and cancer, and their potential for use in novel gene therapy approaches to disease treatment, the book gives an up to the minute account of active macrophage research. The editors have intentionally included a broad rangeof topics that will appeal
not only to immunologists and cell biologists but will also be of interest to those working in the specific disease areas covered.

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Human Antibody Therapeutics For Viral Disease

Human Antibody Therapeutics For Viral Disease (Current Topics in Microbiology and Immunology)
by Scott K. Dessain (Editor)

Product Details
* Hardcover: 190 pages
* Publisher: Springer; 1 edition (December 6, 2007)
* Language: English
* ISBN-10: 3540721444

Book Description
Although the utility of human antibodies as medical therapeutics for cancer and immune diseases has been well-established, it is only beginning to be realized for the treatment of viral infectious diseases. Polyclonal immunoglobulins have long been used for some viral diseases, but they have limited potency and disease scope. It should theoretically be possible to create monoclonal or oligoclonal antibody preparations that capture the essential curative functions of the humoral immune response to viral pathogens, yet only a single humanized monoclonal antibody (pavilizumab) has been approved as a viral countermeasure. Reliable technologies for creating human or humanized antibodies with defined viral antigen specificities are well-established. Accordingly, current antibody development efforts are focused on identifying and cloning the particular antibodies that contain the fundamental curative potency of the polyclonal humoral immune response.

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