Immunobiology of Natural Killer Cell Receptors

Immunobiology of Natural Killer Cell Receptors (Current Topics in Microbiology and Immunology)
by Eric Vivier (Editor), Marco Colonna (Editor)

Product Details:
* Hardcover: 286 pages
* Publisher: Springer; 1 edition (December 1, 2005)
* Language: English
* ISBN-10: 3540260838

Book Description
Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.

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Infectious Diseases and Substance Abuse

Infectious Diseases and Substance Abuse (Infectious Agents and Pathogenesis)
by Herman Friedman (Editor), Thomas W. Klein (Editor), Mauro Bendinelli (Editor)

Product Details:
* Hardcover: 211 pages
* Publisher: Springer; 1 edition (August 26, 2005)
* Language: English
* ISBN-10: 0306486873

Book Description:
The influence of many drugs of abuse – licit and illicit – on immune function has been examined extensively in recent years. Many such substances, including marijuana, cocaine, morphine, and nicotine, have been shown to enhance the disease process by impairing immunologic function. Use of these drugs impairs immunologic functions by suppressing antibody function, decreasing cytokine production, enhancing production and release of IL1, and suppressing IL2 and interferon. Among the viruses known to be effected by these drugs are viruses such as herpes simplex virus and murine retrovirus and bacterial agents such as Staphylococcus, Listeria, Treponema, and Legionella.

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