Bacterial Pathogenesis: Methods and Protocols

Bacterial Pathogenesis: Methods and Protocols (Methods in Molecular Biology)
by Frank DeLeo (Editor), Michael Otto (Editor)

Product Details
Hardcover: 414 pages
Publisher: Humana Press; 1 edition (January 31, 2008)
Language: English
ISBN-10: 1588297403

Book Description
Bacterial infections affect world health today as a leading cause of morbidity and mortality. Pathogenic bacteria routinely command a broad spectrum of niches in the human host, making an understanding of pathogenesis mechanisms crucial to the development of prophylactics and treatment for bacterial diseases. A variety of in vitro methods, in vivo animal model systems and cutting-edge genomics assays have arisen in the effort to study bacterial pathogenesis and identify potential therapeutic targets. In Bacterial Pathogenesis, in-depth methods and state-of-the-art protocols are presented for investigating specific mechanisms of pathogenesis for a wide range of bacteria. This invaluable collection includes protocols to study host-pathogen interactions, animal models of infection, and novel approaches to identifying therapeutic targets designed to control infections. Up-to-date molecular typing methods for Staphylococcus aureus and a new model of streptococcal pharyngitis in non-human primates are also included. Bacterial Pathogenesis will prove an invaluable collection for microbiologists, immunologists, cell biologists and infectious disease clinicians - and indispensable to all science researchers interested in studying pathogenic bacteria and related disease processes.

Download

Mirror

The Third Domain - The Untold Story of Archaea

The Third Domain
by Tim Friend (Author)

Product Details
Hardcover: 312 pages
Publisher: Joseph Henry Press; 1 edition (July 12, 2007)
Language: English
ISBN-10: 0309102375

Book Description
The Third Domain is the untold story of how the discovery of a new form of life--one ignored for the past thirty years by mainstream scientists--is revolutionizing science, industry, and even our search for the existence of life beyond Earth.
For most of the history of science, people have been taught that the tree of life consists of two branches--one represented by bacteria and the other by all of the multi-celled organisms, including plants and animals. Few people realize that there is a third branch on that tree, or a third domain of life.
The scientific community was, therefore, shocked when in 1977, a lone scientist named Carl Woese determined that the archaea - biochemically and genetically unique organisms that live and thrive in some of the most inhospitable environments on Earth - were a distinct form of life, unlike anything seen on Earth before. It was an astonishing discovery. Initially labeled as an unimportant and novel form of bacteria, today key leaders of the scientific community are calling the archaea one of the most important scientific revelations of the 20th century.
The Third Domain tells the story of their strange potential - maverick entrepreneur Craig Venter now believes that the archaea holds critical importance to the biotech industry - and investigates their incredible history - many believe that they are the oldest form of life on Earth - to provide a riveting account of an astonishing discovery.

Download

Graft-Versus-host Disease

Graft-Versus-host Disease (Medical Intelligence Unit)
by Nelson J. Chao (Author)

Product Details
Hardcover: 132 pages
Publisher: Landes Bioscience; 2nd edition (March 15, 1999)
Language: English
ISBN-10: 1570595348

Book Description
This book provides a historical perspective of graft-vs-host disease as well as the discussion of the mechanisms involved in graft-vs-host disease. Understanding the mechanisms of graft-vs-host disease will allow for the development of better preventative and therapeutic measures. This field continues to be an area of active research as we understand better and better how T-cells become activated and the important factors associated with activated T-cells such as specific cytokines released or specific cytokines which may effect T-cell functions. These particular aspects are covered in this book as well as a discussion on the potential therapies and prophylactic regimens associated with graft-vs-host disease.

Download

Advances in Antiviral Drug Design, Volume 5

Advances in Antiviral Drug Design, Volume 5 (Advances in Antiviral Drug Design)
by E. De Clercq (Editor(

Product Details
Hardcover: 250 pages
Publisher: Elsevier Science; 1 edition (August 28, 2007)
Language: English
ISBN-10: 0444521739

Book Description
Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.

Download

Advances in Antiviral Drug Design, Volume 4

Advances in Antiviral Drug Design, Volume 4 (Advances in Antiviral Drug Design)
by E. De Clercq (Editor)

Product Details
Hardcover: 230 pages
Publisher: Elsevier Science; 1 edition (December 17, 2003)
Language: English
ISBN-10: 0444506020

Book Description
The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses six specific directions that have opened new avenues for the treatment of HIV and other virus infections.
First, as the introductory chapter, the different new anti-HIV agents that are now in preclinical or clinical development are reviewed by E. De Clercq. This includes new NRTIs, NNRTIs and PIs, but also HIV entry/fusion inhibitors as well as integrase inhibitors, and some of these agents, such as the NRTI emtricitabine [(-)FTC] and the PI atazanavir, may soon be licensed for clinical use.
Second, high expectations are vested in the potential therapeutic usefulness of inhibitors of HIV integration, a point of no return in the life cycle of HIV, and this approach is highlighted by D.J. Hazuda and S.D. Young.
Third, as all currently available PIs can be described as "peptidomimetic", and, therefore, expected to demonstrate overlapping virus-drug resistance and side effect profiles, it would be interesting to see how a non-peptidic protease inhibitor such as tipranavir behaves, and this is covered by D. Mayers, K. Curry, V. Kohlbrenner and S. McCallister.
Fourth, neuraminidase inhibitors such as zanamivir (that has to be inhaled) and oseltamivir (that can be administered via the oral route) have gained a definitive status as antiviral drugs useful for both therapy and prophylaxis of influenza A and B virus infections; as they target a specific influenza viral enzyme, neuraminidase (or sialidase), they may be expected to block newly emerging influenza viruses as well, and the design of neuraminidase inhibitors has received due attention of H. Jin and C.U. Kim.
Fifth, while the major current efforts in antiviral drug development have shifted from herpesviruses towards HIV and hepatitis viruses [hepatitis B virus (HBV), hepatitis C virus (HCV)], it is interesting to note that by switching from the classical five-membered sugar or acyclic nucleoside strategy, J. Wang, M. Froeyen and P. Herdewijn have gone "upstream" in designing six-membered carbocyclic nucleosides as potential anti-herpesvirus agents.
Sixth, following up on the nucleotide prodrug strategy introduced above under ix, to deliver the biologically active nucleotides inside the cells, C. Meier has elaborated on a particular class of such pronucleotides, namely that of the cyclosaligenyl pronucleotides, an approach that should have far reaching implications for compounds effective against HIV, HBV and other viruses.
The six topics covered in this fourth volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the design and development of new therapeutic agents for virus infections. They pertain to the combat against three of the most important viral pathogens of current times: HIV, HBV, influenza virus and herpesviruses.

Download

Advances in Antiviral Drug Design, Volume 3

Advances in Antiviral Drug Design, Volume 3 (Advances in Antiviral Drug Design)
by E. De Clercq (Editor)

Product Details
Hardcover: 248 pages
Publisher: Elsevier Science; 1 edition (October 1, 1999)
Language: English
ISBN-10: 0762302011

Book Description
Volume 3 of Advances in Antiviral Drug Design is keeping up with the recent progress made in the field of antiviral drug research and highlights five specific directions that have opened new avenues for the treatment of virus infections.
First, the use of lamivudine (3TC) for the treatment of HIV infections, and its more recent introduction for the treatment of hepatitis B virus (HBV) infections, has heralded the transition of D- to L-nucleosides in the antiviral nucleoside drug design, and it is likely that the future will provide more nucleosides of the L-configuration, such as (-)FFC (emtricitabine) and L-FMAU, as will be described by J.-C.G. Graciet and R.F. Shinazi.
Second, the acyclic purine nucleoside phosphonates, i.e. PMEA (adefovir and PMPA (tenofovir), offer great potential as both anti-HIV and anti-HBV agents, and both compounds have been the subject of advanced clinical trials in their oral produrg form (adefovir dipivoxil and tenofovir disoproxyl), as mentioned by M.N. Arimilli, J.P. Dougherty, K.C. Cundy, and N. Bischofberger.
Third, with the advent of nevirapine, delavirdine, and efavirenz, the NNRTIs have definitely come of age. Emivirine (MKC-442), a derivative of the original HEPT analog that was described in 1989 has now proceeded through pivotal clinical studies, and how this class of compounds evolved is presented in the account of H. Tanaka and his colleagues.
Fourth, at the end of 1999, anticipating on the next winter influenza offensive, we should have at end two compounds that specifically inhibit influenza A and B virus infections: zanamivir (by the intranasal route) and oseltamivir (by the oral route). Both compounds have proved effective in the prophylaxis and treatment of influenza A and B virus infections and act through the same mechanism; that is by blocking the viral neuraminidase (or sialidase), a key enzyme that allows the virus to spread from one cell to another (within the respiratory mucosal tract). The design of these sialidase inhibitors will be presented by M. von Itzstein and J.C. Dyason.
Fifth, the discovery (in 1996) of the chemokine receptors CXCR4 and CCR5 as essential coreceptors (in addition to the CD4 receptor) for HIV entry into the cells, has boosted an enormous interest in potential antagonists of these receptors. The bicyclams represent the first low-molecular-weight compounds targeted at CXCR4, the coreceptor used by the more pathogenic, T-lymphotropic, HIV strains, to enter the cells. They will be addressed by G.J. Bridger and R.T. Skerlj.
The five topics covered in this third volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the chemotherapy of virus infections. They pertain to the combat against three of the most important virus infections of current times: HIV, HBV, and influenza virus.

Download

Minor Histocompatibility Antigens: From the Laboratory to the Clinic

Minor Histocompatibility Antigens: From the Laboratory to the Clinic (Molecular Biology Intelligence Unit 8)
by Derry Roopenian (Author)

Product Details
Hardcover: 185 pages
Publisher: LANDES BIOSCIENCE PUBLISHERS; 1 edition (February 1, 2000)
Language: English
ISBN-10: 1570595992

Book Description
With the widespread application of solid tissue and bone marrow transplantation as a treatment for an array of life threatening disorders, there is a pressing need for clinicians and experimentalists to understand the basis of immunological rejection of tissue transplants. While much previous work focuses on characterization of antigens encoded by the major histocompatibility complex (MHC) in this process, the many histocompatibility (H) antigens encoded outside of the MHC, the so-called minor H antigens, have only recently been identified at the molecular level. This easily readable but comprehensive text is the first to put together insightful historic perspectives with up-to-date advances in the molecular genetics, biochemistry and immunobiology of minor H antigens from both experimental and clinical points of view. In doing so it provides a sourcebook particularly suited for clinicians and experimental immunologists engaged in tissue transplantation.

Download

Fungal Allergy and Pathogenicity

Fungal Allergy and Pathogenicity (Chemical Immunology)
by Michael Breitenbach (Author), Reto Crameri (Author), Samuel B. Lehrer (Author)

Product Details
Hardcover: 310 pages
Publisher: Not Avail; 1 edition (May 2002)
Language: English
ISBN-10: 380557391X

Download

Microbiologically Influenced Corrosion: An Engineering Insight

Microbiologically Influenced Corrosion: An Engineering Insight (Engineering Materials and Processes)
by Reza Javaherdashti (Author)

Product Details
Hardcover: 164 pages
Publisher: Springer; 1 edition (March 12, 2008)
Language: English
ISBN-10: 1848000731

Book Description
Microbiologically-influenced corrosion (MIC) is one of the greatest mysteries of corrosion science and engineering, due to the complexities resulting from the involvement of living things such as bacteria. Bacteria are not only able to affect our health, but are also capable of impacting upon everyday life through a wide range of industrial sectors and the economy.
Microbiologically Influenced Corrosion: An Engineering Insight introduces a new approach to the basics of MIC and explains how to recognise, understand, mitigate and/or prevent this type of corrosion. Topics explored include stress corrosion cracking and microbial corrosion, the pros and cons of biocides, the involvement of magnetic bacteria in microbial corrosion, and a new interpretation of cathodic protection based on recent research in microbial environments.
The material covered by Microbiologically Influenced Corrosion: An Engineering Insight will be of benefit to professional and consultant engineers in power generating, oil and gas, marine, and mining industries; as well as to researchers in the fields of chemistry, chemical engineering, materials science, corrosion and mechanical engineering.

Download

Mirror

Psychoneuroimmunology, Two-Volume Set

Psychoneuroimmunology, Two-Volume Set, Volume 1-2, Fourth Edition
by Robert Ader (Editor)

Product Details
Hardcover: 1320 pages
Publisher: Academic Press; 4 edition (September 21, 2006)
Language: English
ISBN-10: 012088576X

Book Description:
Psychoneuroimmunology is the study of interactions among behavioral, neural and endocrine, and immunologic processes of adaptation. These two volumes provide a clearly written, extensively referenced summary of some of the behavioral, neural and endocrine regulators of immune responses and immunologically mediated disease processes and of the behavioral and neuroendocrine effects of immune system activity. Several chapters expand upon topics reviewed in earlier editions of this series; most chapters cover active areas of research that have not previously been reviewed. As illustrated in this fourth edition, interdisciplinary research continues to provide evidence that the brain and immune system represent a single, integrated system of defense.

Download

Conquering Hepatitis C

Conquering Hepatitis C
by Willis C. Maddrey (Author)

Product Details
Paperback: 108 pages
Publisher: BC Decker Inc.; 1st edition (June 15, 2000)
Language: English
ISBN-10: 1896998062

Book Description
Hepatitis C is a serious viral illness that affects the liver. Most often spread by blood-to-blood contact, the majority of people infected with hepatitis C do not know they are infected until liver damage has occurred. Because the hepatitis C virus changes its form frequently, presently there is no vaccine for HCV; but once diagnosed, effective treatment is available for many. Written for people diagnosed with hepatitis C and under the care of a physician, this informative book is designed to answer questions about the condition and allow the reader to play an active role in its treatment.

Download

Mirror

Food-Borne Pathogens: Methods and Protocols

Food-Borne Pathogens: Methods and Protocols (Methods in Biotechnology)
by Catherine Adley (Editor)

Product Details
Hardcover: 280 pages
Publisher: Humana Press; 1 edition (October 6, 2005)
Language: English
ISBN-10: 158829465X

Book Description
A collection of readily reproducible classic and emerging molecular methods for the laboratory isolation and identification of the pathogens, viruses, and parasites that cause food-borne disease. Among the pathogens covered are specific bacteria, including Salmonella spp, Campylobacter spp., Listeria spp., and Bacillus spp.; viruses, including noroviruses and enteroviruses; and parasites, including Cryptosporidium and seafood nematode worms. The protocols follow the successful Methods in Biotechnology series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.

Download

Mirror

Enzyme & Microbial Biosensors: Techniques and Protocols

Enzyme & Microbial Biosensors: Techniques and Protocols (Methods in Biotechnology)
by Ashok Mulchandani (Editor), Kim Rogers (Editor)

Product Details
Hardcover: 284 pages
Publisher: Humana Press; 1st edition (May 15, 1998)
Language: English
ISBN-10: 0896034100

Book Description
A cutting-edge collection of detailed, step-by-step techniques and protocols for constructing, evaluating, and using enzyme- and microbial-based biosensors. Ideal for novices starting research in their field or experienced researchers wanting to use a biosensor for a specific analytical measurement, the methods detailed here allow biochemists, analytical chemists, microbiologists, and engineers to successfully apply biosensor technology to their specific problems. The techniques include classical enzyme biosensors based on potentiometric, amperometric, conductimetric, optical, and thermal transducers, as well cell-based biosensors based on amperometric and optical transducers. A companion volume, Affinity Biosensors: Protocols and Techniques, by Rogers & Mulchandani, concentrates on cell- and affinity-based biosensors.

Download

Mirror

Molecular Medical Microbiology

Molecular Medical Microbiology (3-Volume Set)
by Max Sussman (Editor)

Product Details
Hardcover: 2223 pages
Publisher: Academic Press; 1st edition (October 2001)
Language: English
ISBN-10: 0126775303

Book Description:
The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource.
This timely and authoritative 3-volume work is an invaluable reference source of medical bacteriology. Comprising over 100 chapters, organised into 17 major sections, the scope of this impressive work is wide-ranging.
Written by experts in the field, chapters include cutting edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology.
KEY FEATURES:
* The first comprehensive and accessible reference on Molecular Medical Microbiology
* Two color presentation throughout
* Full colour plate section
* Fully integrated and meticulously organised
* In depth discussion of individual pathogenic bacteria in a system-oriented approach
* Includes a clinical overview for each major bacterial group
* Presents the latest information on vaccine development, molecular technology and diagnostic technology
* Extensive indexing and cross-referencing throughout
Over 100 chapters covering all major groups of bacteria
* Written by an international panel of authors expert in their respective disciplines
* Over 2300 pages in three volumes

Download - Vol1 - Part1 Part2, Vol2, Vol3

Paleomicrobiology: Past Human Infections

Paleomicrobiology: Past Human Infections
by Didier Raoult (Editor), Michel Drancourt (Editor)

Product Details
Hardcover: 226 pages
Publisher: Springer; 1 edition (February 2008)
Language: English
ISBN-10: 3540758542

Book Description
"Paleomicrobiology Past Human Infections" features the methods and main achievements in this emerging field of research at the intersection of microbiology and evolution, history and anthropology. New molecular approaches have already provided exciting results, such as confirmation of a single biotype of Yersinia pestis as the causative agent of historical plague pandemics, and the closer proximity of Mycobacterium tuberculosis from ancient skeletons to modern strains than to Mycobacterium bovis, shedding new light on the evolution of major human pathogens and pathogenpopulation relationships. Firm microbiological diagnoses also provide historians and anthropologists with new data on which to base evaluation of past epidemics.

Download

Mirror

Public Health and Preventive Medicine

Public Health and Preventive Medicine (Maxcy-Rosenau-Last Public Health and Preventive Medicine)
by Robert B. Wallace (Author)

Product Details
Hardcover: 1416 pages
Publisher: McGraw-Hill Medical; 15 edition (September 21, 2007)
Language: English
ISBN-10: 0071441980

Book Description
An extensive, in-depth look at public health and preventive medicine topics from experts in the field
This trusted one-stop resource is a completely up-to-date, all-in-one public health and preventive medicine guide. Sponsored by the Association of Teachers of Preventive Medicine and edited and written by well-respected authorities in the range of topics covered, Maxcy-Rosenau-Last Public Health and Preventive Medicine is also an outstanding guide to additional resources of information in preparing for the board exam in preventative medicine and public health.
The new edition of Maxcy-Rosenau-Last Public Health and Preventive Medicine has been completely updated to encompass many new diseases, conditions, and policy issues that continue to dramatically shape-and expand the influence of-public health and preventive medicine.
New to this Edition:
Important coverage of new diseases, conditions, and policy issues, including critical lessons learned from the SARS epidemic, the most recent perspectives on monkey pox, plus an increased emphasis on West Nile Virus
Restructured infectious and communicable disease section that reflects the emergence of many emerging and recrudescent conditions
Greater focus on existing web-based resources for further reading
New information on community-based participatory research
Timely new chapter on bioterrorism and preparedness
Additional insights on the amelioration of disease-producing lifestyles
Research-enhancing lists and catalogs based on federal and other public access databases that are relevant to public health and prevention
More streamlined coverage of chemical exposures and diseases overall
Essentials of the public health service delivery infrastructure

Download

Mirror

Diagnostic Testing of Allergic Disease

Diagnostic Testing of Allergic Disease (CLINICAL ALLERGY AND IMMUNOLOGY)
by Kemp/Lockey (Author)

Product Details
Hardcover: 352 pages
Publisher: Informa Healthcare; 1 edition (March 1, 2000)
Language: English
ISBN-10: 0824703030

Book Description
This all-inclusive reference takes a rational approach to the use and interpretation of the most important clinical and laboratory immunology tests available for confirming the presence of immune dysfunction and guiding therapy-including every major allergy test for the first time in a single source. Facilitates objective discussion between patients and physicians or other health care professionals by including unconventional and unproven tests! Providing a better understanding of the indications, benefits, and limitations of current tests, Diagnostic Testing of Allergic Disease · discusses percutaneous and intracutaneous testing · explains patch and delayed-type hypersensitivity testing · describes rhinoscopy, ophthalmoscopy, ocular biopsy and culture, otoscopy, and audiometry · covers food and nasal challenges, and specific tests for urticaria and angioedema · spotlights in vitro assays including RAST, ELISA, immunoblots, and basophil histamine release tests · examines spirometry and bronchoscopy · focuses on in vivo and in vitro assays for drug reactions · outlines radiographic imaging methods and interpretations · and more! With more than 600 references, photographs, micrographs, tables, and drawings, Diagnostic Testing of Allergic Disease serves allergists and clinical immunologists, dermatologists, otolaryngologists, internists, pediatricians, family practitioners, and other health care professionals, medical school, and graduate students in these disciplines.

Download

Emerging Issues on HPV Infections: From Science to Practice

Emerging Issues on HPV Infections: From Science to Practice
by Joseph Monsonego (Editor)

Product Details
Hardcover: 275 pages
Publisher: S. Karger AG (Switzerland); 1 edition (April 11, 2006)
Language: English
ISBN-10: 3805581203

Book Description
Despite the substantial efforts made to prevent the disease by early detection, cervical cancer remains a leading cause of mortality among women worldwide. The European Research Organization on Genital Infection and Neoplasia (EUROGIN) pursues a wide variety of educational and training activities, aiming to spread accurate and state-of-the-art information in the field of cervical cancer prevention. The latest outcome of these activities is presented in this book. Providing a concise update of the current knowledge on human papillomavirus (HPV) infections and their intimate link to cervical cancer, the book focuses on five interrelated topics: high- and low-risk HPV infections, methods for HPV detection and use of molecular markers, HPV testing in primary screening and patient management, morphological diagnosis and treatment, as well as prevention of cervical cancer by vaccines. Written by leading international experts, this publication is targeted at a multidisciplinary readership consisting of health care professionals from diverse specialties engaged in the management of HPV-associated diseases.

Download

Mirror

Applied Microbiology

Applied Microbiology (Focus on Biotechnology)
by A. Durieux (Editor), J.-P. Simon (Editor)

Product Details
Hardcover: 288 pages
Publisher: Springer; 1 edition (May 31, 2001)
Language: English
ISBN-10: 079236858

Book Description
This book illustrates the major trends in applied microbiology research with immediate or potential applications. The diversity of the chapters allows coverage of a large field of applications, such as food and health sectors, environmental technology, and fine chemical productions. It includes specific research papers and overview papers, and attempts to provide a balanced coverage of various types of micro-organisms, particularly yeast, fungi, and bacteria. It presents results of recent researches, which have immediate application. Audience: The book is intended for research workers in microbiology, in food fermentation, and also to researchers in metabolic engineering. Furthermore, this book will be of interest to people from the academic world and the biotechnological industry.

Download

Mirror

Password:twilightzone

Viral Neuropathies in the Temporal Bone

Viral Neuropathies in the Temporal Bone (Advances in Otorhinolaryngology)
by Richard R. ed. Gacek (Author)

Product Details
Hardcover: 139 pages
Publisher: Karger; 1 edition (2002)
Language: English
ISBN-10: 3805572956

Book Description
New morphologic evidence in human temporal bones from patients with vestibular neuronitis, Meniere's Disease, benign paroxysmal positional vertigo, and idiopathic facial paralysis is put forward to support the concept that these neuropathies are caused by re-activation of a latent neurotropic virus (Herpes family) located in the sensory ganglia. Previously unreported changes indicate that the efferent neuronal pathways to the auditory and vestibular end organs may degenerate as a result of their course through the inflamed vestibular ganglion. Such paralysis of the efferent system may be responsible for secondary symptoms (tinnitus, motion intolerance) associated with these neuropathies. Case histories with magnetic resonance imaging of the seventh and eighth cranial nerves are described in support of the viral neuropathy concept. In conclusion, some thoughts on the limitations and effectiveness of antiviral therapy are presented. The book provides an explanation for understanding and treating the various symptoms associated with vertigo and idiopathic facial paralysis for all clinical specialists who treat patients suffering from these disorders.

Download

Mirror

Replication-Competent Viruses for Cancer Therapy

Replication-Competent Viruses for Cancer Therapy (Monographs in Virology)
by Pablo Hernaiz Driever (Editor), S. D. Rabkin (Editor)

Product Details
Hardcover: 188 pages
Publisher: S Karger Pub (November 2001)
Language: English
ISBN-10: 3805572484

Download

Mirror

Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols

Methicillin-Resistant Staphylococcus aureus (MRSA) Protocols (Methods in Molecular Biology)
by Yinduo Ji (Editor)

Product Details
Hardcover: 264 pages
Publisher: Humana Press; 1 edition (September 27, 2007)
Language: English
ISBN-10: 1588296555

Book Description
MRSA Protocols for Methods in Molecular Biology provides a comprehensive collection of the most up-to-date techniques for the detection and investigation of MRSA. Each chapter begins with a brief introduction to the method and purpose and then goes into detailed protocols for every step of analysis. Several chapters also include a section with tips on individual steps not usually found in methods books. These tips may represent the difference between immediate success and lengthy troubleshooting.
Among the topics discussed in this volume are Staphylococcus aureus infections, MIC analysis, ITS-PCR identification, SCCmec analysis, and Biofilm formation. The book also contains helpful case studies, and authors provide insights into the control, prevention, and treatment of infections.
Oriented towards routine clinical diagnosis, research, and actual practice for treatment of patients infected by MRSA, MRSA Protocols for Methods in Molecular Biology will make a useful basis for anyone interested in instituting a new method for studying MRSA.

Download

Mirror

Handbook of Prebiotics

Handbook of Prebiotics
by Glenn R. Gibson (Editor), Marcel Roberfroid (Editor)

Product Details
Hardcover: 504 pages
Publisher: CRC (January 29, 2008)
Language: English
ISBN-10: 0849381711

Book Description
In order to achieve optimal digestion, absorption, and nutritional health, we must have appropriate populations of positive microflora. Prebiotics are functional foods that improve health by fortifying indigenous probiotics within the gut. This fast-growing area of nutrition and microbiology is rapidly amassing data and answering many questions about the necessity and benefit of such functional foods.
Gathering contributions from leading experts in a range of disciplines, Handbook of Prebiotics presents a balanced view of the current knowledge in many different areas of the field. It discusses concept, definition and criteria for classification of a food component as prebiotics It then describes interactions with gut microbiota. Highlighting varying levels of evidence and agreement, the book presents current arguments for and against prebiotic intake. Contributions discuss the biomechanics of prebiotics and their effects on immune status, serum lipid concentrations, mineral bioavailability, and satiety modulation. They consider the health implications of prebiotic intake such as reduced incidence of gastroenteritis and chronic pathogenic gut disorders, including intestinal cancers and inflammatory bowel diseases.
Providing well-rounded coverage, the book explores the varying effects of prebiotics in different populations and age groups such as infants and the elderly, as well as livestock and pets. The final chapters describe food avenues and the safety implications for prebiotic use. Spanning several disciplines including food science, nutrition, microbiology, biotechnology, and the health sciences, this seminal work makes a point to include sound research science and well-balanced views on the potential of prebiotics for promoting good health.

Download

Mirror

Nature Reviews Immunology Feb 2008

Nature Reviews Immunology Feb 2008

Download

Mirror

Handbook on Clostridia

Handbook on Clostridia
by Peter Duerre (Editor)

Product Details
Hardcover: 920 pages
Publisher: CRC; 1 edition (June 15, 2004)
Language: English
ISBN-10: 0849316189

Book Description
Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research articles, reviews, and book chapters. Responding to this gap in the literature, Handbook on Clostridia combines all of these topics into a single volume. The editor takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications. Providing a comprehensive resource on the complete field of Clostridium, this book also serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist, researcher, and student involved in this promising field.

Download - Part1 Part2 Part3 Part4 Part5 Part6 Part7

Mirror - Part1 Part2 Part3 Part4 Part5 Part6 Part7

Mechanisms Of Dna Tumor Virus Transformation

Mechanisms Of Dna Tumor Virus Transformation (Monographs in Virology)
by Leonard J. ed. Rosenthal (Author)

Product Details
Hardcover: 163 pages
Publisher: Karger; 1 edition (2001)
Language: English
ISBN-10: 3805572476

Download

Genomics of Disease

Genomics of Disease (Stadler Genetics Symposia Series)
by J.P. Gustafson (Editor)

Product Details
Hardcover: 240 pages
Publisher: Springer; 1 edition (March 7, 2008)
Language: English
ISBN-10: 0387767223

Book Description
The title will develop from the 24th Stadler symposium. It will explore the general theme "GENOME EXPLOITATION: Data Mining the Genomes". The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book will present a state-of-the-art picture on mining the Genome databases. This will be one of the few times that researchers in both plants and animals will be working together to create a seminal data resource.

Download

Mirror

IgA Nephropathy Today

IgA Nephropathy Today (Contributions to Nephrology)
by Y. Tomino (Author)

Product Details
Hardcover: 256 pages
Publisher: S. Karger AG (Switzerland) (May 31, 2007)
Language: English
ISBN-10: 3805582862

Download

Mirror

Medical Microbiology for the New Curriculum: A Case-Based Approach

Medical Microbiology for the New Curriculum: A Case-Based Approach
by Roberta B. Carey (Author), Mindy G. Schuster (Author), Karin L. McGowan (Author)

Product Details
Paperback: 289 pages
Publisher: Wiley-Liss; 1 edition (December 17, 2007)
Language: English
ISBN-10: 0471479330

Book Description
Medical Microbiology for the New Curriculum: A Case-Based Approach encompasses twenty-three cases of the most clinically important and frequently encountered infectious diseases and the organisms that cause them. This text integrates basic microbiology principles with relevant pathology, pharmacology and clinical features of the diseases. Each fully illustrated case study teaches the reader how to solve cases in a consistent, systematic fashion using determinations about differential diagnosis, laboratory tests, mechanisms of pathogenesis, treatment, and infection control.

Download

Biology of Disease

Biology of Disease
by Nessar Ahmed (Author)

Product Details
Paperback: 576 pages
Publisher: BIOS Scientific Publ; 1 edition (December 13, 2006)
Language: English
ISBN-10: 0748772103

Book Description
Biology of Disease is a text for undergraduate biomedical students who are intending to pursue a career in the medical support services. Written in an engaging manner, it is also an ideal reference for medical and clinical technicians and will be useful for students needing a broad overview of the biological basis of disease. Specific areas covered include haematology, immunology, and microbiology, along with genetic, cardiovascular, and diet-related disorders. Cancer and diseases of ageing are also included.
Extensively illustrated throughout, the text is further supported by bullet-point summaries and revision questions. Biology of Disease also contains examples and case studies of common diseases, discussing preventative measures and treatments.

Download

Mirror

Microbial Biotechnology: Fundamentals of Applied Microbiology

Microbial Biotechnology: Fundamentals of Applied Microbiology
by Alexander N. Glazer (Author), Hiroshi Nikaido (Author)

Product Details
Hardcover: 576 pages
Publisher: Cambridge University Press; 2 edition (October 1, 2007)
Language: English
ISBN-10: 0521842107

Book Description
Knowledge in microbiology is growing exponentially through the determination of genomic sequences of hundreds of microorganisms and the invention of new technologies such as genomics, transcriptomics, and proteomics, to deal with this avalanche of information.
These genomic data are now exploited in thousands of applications, ranging from those in medicine, agriculture, organic chemistry, public health, biomass conversion, to biomining. Microbial Biotechnology. Fundamentals of Applied Microbiology focuses on uses of major societal importance, enabling an in-depth analysis of these critically important applications. Some, such as wastewater treatment, have changed only modestly over time, others, such as directed molecular evolution, or 'green' chemistry, are as current as today's headlines.
This fully revised second edition provides an exciting interdisciplinary journey through the rapidly changing landscape of discovery in microbial biotechnology. An ideal text for courses in applied microbiology and biotechnology courses, this book will also serve as an invaluable overview of recent advances in this field for professional life scientists and for the diverse community of other professionals with interests in biotechnology.

Download

The Epidemic: A Global History of AIDS

The Epidemic: A Global History of AIDS
by Jonathan Engel (Author)

Product Details
Hardcover: 400 pages
Publisher: Collins; 1 edition (September 19, 2006)
Language: English
ISBN-10: 0061144886

Book Description
From the Castro bathhouses to AZT and the denial of AIDS in South Africa, this sweeping look at AIDS covers the epidemic from all angles and across the world. Engel seamlessly weaves together science, politics, and culture, writing with an even hand—noting the excesses of the more radical edges of the ACT UP movement as well as the conservative religious leaders who thought AIDS victims deserved what they got.
The story of AIDS is one of the most compelling human dramas of our time, both in its profound tragedy and in the extraordinary scientific efforts impelled on its behalf. For gay Americans, it has been the story of the past generation, redefining the community and the community's sexuality. For the Third World, AIDS has created endless devastation, toppling economies, social structures, and whole villages and regions. And the worst may yet be to come: AIDS is expanding quickly into India, Russia, China, and elsewhere, while still raging in sub-Saharan Africa.
A distinguished medical historian, Engel lets his characters speak for themselves. Whether gay activists, government officials, public health professionals, scientists, or frightened parents of schoolchildren, they responded as best they could to tragic happenstance that emerged seemingly from nowhere. There is much drama here, and human weakness and heroism too. Writing with vivid immediacy, Engel allows us to relive the short but tumultuous history of a modern scourge.

Download

Mirror

HIV I: Molecular Biology and Pathogenesis: Clinical Application

HIV I: Molecular Biology and Pathogenesis: Clinical Applications, Volume 56, Second Edition
by Kuan-Teh Jeang (Editor), J. Thomas August (Series Editor), Ferid Murad (Series Editor)

Product Details
Hardcover: 500 pages
Publisher: Academic Press; 2 edition (December 11, 2007)
Language: English
ISBN-10: 0123736013

Book Description:
Although it is one of the most-widely studied viruses, many mysteries still remain about HIV. Covering the latest advances and challenges associated with clinical application of new antiviral drugs and vaccines, this revised edition is a companion to Murad:HIV-1: Molecular Biology and Pathogenesis, 2E. Leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus.
* The latest developments in HIV-vaccine research
* New concepts in the discovery and design of novel anti-HIV drugs

Download

Mirror

Metal Ions in Fungi

Metal Ions in Fungi (Mycology, Vol 11)
by Gunther Winkelmann (Editor)

Product Details
Hardcover: 528 pages
Publisher: CRC (February 11, 1994)
Language: English
ISBN-10: 082479172X

Book Description
Presents the latest advances in the study of the intracellular fate and transport of metal ions in fungi, emphasizing the mechanisms that regulate cellular concentration. The book explains the expanding relationship between molecular genetics and inorganic biochemistry.

Download

Mirror

Fungal Genetics: Principles and Practice

Fungal Genetics: Principles and Practice (Mycology Series, Vol 13)
by Cees Bos (Editor)

Product Details
Hardcover: 442 pages
Publisher: CRC; 1st edition (March 15, 1996)
Language: English
ISBN-10: 082479544X

Book Description
This is a concise guide to the combined use of classical and molecular methods for the genetic analysis and breeding of fungi. It presents basic concepts and experimental designs, and demonstrates the power of fungal genetics for applied research in biotechnology and phytopathology. Case studies of Saccharomyces cerevisiae, Candida albicans, Aspergillus niger, Neurospora crassa, Podospora anserina, Phytophthora infestans and others are included.

Download

Mirror

Molecular Techniques in the Microbial Ecology of Fermented Foods

Molecular Techniques in the Microbial Ecology of Fermented Foods (Food Microbiology and Food Safety)
by Luca Cocolin (Editor), Danilo Ercolini (Editor)

Product Details
Hardcover: 284 pages
Publisher: Springer; 1 edition (November 9, 2007)
Language: English
ISBN-10: 038774519X

Book Description
With the application of new analytical techniques, the field of food fermentation has grown over last few years. Because of this, the approach to study bacteria in food has changed. Consequently new information is available on the structure and dynamics of microbial populations during fermented food production.
Molecular Techniques in the Microbial Ecology of Fermented Foods provides the latest information and relevant advances on the microbial ecology of fermented foods and the application of molecular methods. This book serves as a guide for students and researchers on the most advanced techniques to identify bacteria and helps in choosing the most appropriate tools to study fermented food from a microbiological point of view.

Download

Mirror

Iron Nutrition in Plants and Rhizospheric Microorganisms

Iron Nutrition in Plants and Rhizospheric Microorganisms
by L.L. Barton (Editor), J. Abadia (Editor)

Product Details
Hardcover: 477 pages
Publisher: Springer; 1 edition (July 28, 2006)
Language: English
ISBN-10: 1402047428

Book Description
This book uses an interdisciplinary approach to provide a comprehensive review on the status of iron nutrition in plants. International scientists discuss research on acquisition of iron by strategy I and strategy II plants. These reviews summarize a variety of plant species and include both laboratory and field observations.
Topics covered in this book include: plants as a source of iron for animals and humans, iron translocation in the plants, iron-stimulated activities that influence crop yield and fruit tree productivity, iron uptake by plants as influenced by microorganisms (i.e. free living soil microorganisms, symbiotic nitrogen-fixing and pathogenic bacteria), the role of plant hormones in iron transport, iron-metal competition in phytoremediation, root zone activities involving interactions between minerals and organic matter, the role of microbial siderophores in rhizospheric iron cycling, iron storage as phytoferritin, proteomic and metabolic studies associated with iron stress response, methods for studying iron metabolism including stable isotopes, and the correction of iron deficiency through the use of synthetic or natural chelates.
Additionally, chapters summarize the use of Arabidopsis to enhance our understanding of the complex activities associated with iron metabolism in plants. This book should serve to stimulate continued exploration of iron activities in plant biology and rhizospheric environments.

Download

Mirror

Fungi in the Environment

Fungi in the Environment (British Mycological Society Symposia)
by Geoffrey Gadd (Editor), Sarah C. Watkinson (Editor), Paul S. Dyer (Editor)

Product Details
* Hardcover: 406 pages
* Publisher: Cambridge University Press; 1 edition (April 23, 2007)
* Language: English
* ISBN-10: 0521850290

Book Description
Fungi are of fundamental importance in the terrestrial environment. They have roles as decomposers, plant pathogens, symbionts, and in elemental cycles. Fungi are often dominant, and in soil can comprise the largest pool of biomass (including other microorganisms and invertebrates). They also play a role in maintenance of soil structure due to their filamentous growth habit and exopolymer production. Despite their important roles in the biosphere, fungi are frequently neglected within broader environmental and microbiological spheres. Additionally, mycological interests can be somewhat fragmented between traditional subject boundaries. This multi-disciplinary volume explores the roles and importance of fungi in the environment. Particular emphasis is given to major research advances made in recent years as a result of molecular and genomic approaches, and in cell imaging and biology. Drawing together microbiologists, mycologists, and environmental scientists, this work is a unique account of modern environmental mycology, and a pivotal contribution to the field.

Download

Mirror

Imaging in SARS

Imaging in SARS
by A. T. Ahuja (Author), C. G. C. Ooi (Author)

Product Details
* Hardcover: 194 pages
* Publisher: Greenwich Medical Media; 1 edition (August 16, 2004)
* Language: English
* ISBN-10: 1841102199

Book Description
Severe acute respiratory syndrome (SARS) is a devastating disease and although the virus would appear to have been contained, it is clear that the impact it has had around the world, and could have again in the future, is immense. Hong Kong has been significantly impacted in the recent SARS outbreak, and clinicians and researchers alike have gained a lot of experience in dealing with the disease at short notice. This new book aims to be a state-of-the art update on SARS, with particular reference to imaging, which plays a crucial role in the diagnosis, management and follow-up of patients with the disease (it is widely accepted that SARS patients cannot be managed without imaging and it is included in the WHO's own list of diagnostic criteria for the disease). The book will also provide a perspective on the treatment and experience of the disease outside Hong Kong.

Download

Mirror

Fluid Sterilization by Filtration

Fluid Sterilization by Filtration, Third Edition
by Peter R. Johnston (Author)

Product Details
Hardcover: 160 pages
Publisher: Informa Healthcare; 3 edition (December 15, 2003)
Language: English
ISBN-10: 0849319773

Book Description
Completely revised and updated, Fluid Sterilization by Filtration, Third Edition discusses the use of gas and fluid filtration systems in sterilization technology. Packed with information useful to both the novice and the expert, it includes line-drawing illustrations, filtration setups, and plots of math functions illustrating fluid flows through filter media built from a random packing of solids. The book provides in-depth discussions of general filtration, specific membranes used in filtration, integrity testing, earlier filtration steps, and cross-flow filtration. It also includes a useful, updated appendix of worldwide contacts and many sources for equipment, supplies, and information.

Download

Mirror

Social Ecology of Infectious Disease

Social Ecology of Infectious Diseases
by Kenneth H. Mayer (Editor), H. F. Pizer (Editor)

Product Details
Hardcover: 440 pages
Publisher: Academic Press; 1 edition (September 24, 2007)
Language: English
ISBN-10: 0123704669

Book Description
Social Ecology of Infectious Diseases explores how human activities enable microbes to disseminate and evolve, thereby creating favorable conditions for the diverse manifestations of communicable diseases. Today, infectious and parasitic diseases cause about one-third of deaths and are the second leading cause of morbidity and mortality. The speed that changes in human behavior can produce epidemics is well illustrated by AIDS, but this is only one of numerous microbial threats whose severity and spread are determined by human behaviors. In this book, forty experts in the fields of infectious diseases, the life sciences and public health explore how demography, geography, migration, travel, environmental change, natural disaster, sexual behavior, drug use, food production and distribution, medical technology, training and preparedness, as well as governance, human conflict and social dislocation influence current and likely future epidemics.
* Provides essential understanding of current and future epidemics
* Presents a crossover perspective for disciplines in the medical and social sciences and public policy, including public health, infectious diseases, population science, epidemiology, microbiology, food safety, defense preparedness and humanitarian relief
* Creates a new perspective on ecology based on the interaction of microbes and human activities.

Download

Mirror

T Cell Subsets, Volume 83: Cellular Selection, Commitment and Identity

T Cell Subsets, Volume 83: Cellular Selection, Commitment and Identity (Advances in Immunology)
by H. Cantor (Editor), Laurie Glimcher (Editor), Frederick W. Alt (Series Editor)

Product Details
Hardcover: 304 pages
Publisher: Academic Press; 1 edition (May 20, 2004)
Language: English
ISBN-10: 0120224836

Book Description
This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity.

Download

Mirror

Foodborne Microbial Pathogens: Mechanisms and Pathogenesis

Foodborne Microbial Pathogens: Mechanisms and Pathogenesis (Food Science Texts Series)
by Arun K. Bhunia (Author)

Product Details
Hardcover: 276 pages
Publisher: Springer; 1 edition (December 12, 2007)
Language: English
ISBN-10: 038774536X

Book Description
Undoubtedly in the past 10-20 years, impact of foodborne pathogens has been overwhelming because of high rate of fatalities, illnesses, and the fear of being exposed to incurable infective agents or toxins. Rapid growth in the centralized food production industries, aggressive agricultural practices and changes in food consumption habits are contributing factors for the emergence of increased foodborne infections by new or old pathogens resulting in several outbreaks, product recalls and economic losses. These events prompted increased research activities to understand the pathogens and their pathogenic mechanisms, and prevention and control strategies. Modern molecular tools also facilitated our understanding of the function and regulations of virulent or other accessory genes. Above all, the complete genome sequence of several important foodborne pathogens helped unravel the molecular basis of pathogenesis.
Foodborne Bacterial Pathogens: Mechanisms and Pathogenisis will be a graduate level textbook focusing on up-to-date information on molecular and cellular mechanism of several major foodborne bacterial pathogens, virulence genes and their regulation in the host or the food environment, pathogenicity testing models, clinical symptoms and prevention and control strategies. In order to understand the disease process, one must have certain understanding about the role of immune system in the disease process. Thus, unlike other textbooks this book will also cover the host parasite interaction to a level where the readers would have better appreciation for the disease mechanism. For the first time a book will link foodborne illness and immunology.
Traditionally, food science or food microbiology has been perceived as a applied science and thus most research programs or teaching curricula did not include topics related to molecular aspect of pathogenesis or mechanism of disease production or survival strategies in food or the host or the influence of food production or processing on pathogens behavior. It is simply because of the lack of adequate knowledge on these topics. As the knowledge base grew and the potential impact of food environment on pathogens behavior is realized, more and more food microbiology training began to emphasize the importance of the basic research and its power of solving practical problems. Therefore, to move this field forward, it is imperative for students, educators and the industry personnel alike to acquire a better understanding of the foodborne pathogens. Hopefully concerted efforts would eventually help formulate strategies that would one day resolve problems with foodborne outbreaks, infections and mortalities.

Download

Mirror

Immunoinformatics

Immunoinformatics (Immunomics Reviews:)
by Christian Schönbach (Editor), Shoba Ranganathan (Editor), Vladim

Product Details
Hardcover: 200 pages
Publisher: Springer; 1 edition (November 26, 2007)
Language: English
ISBN-10: 0387729674

Book Description
This is the first volume in a series that will be dedicated to publishing advances in immunomics particularly those focusing on systemic and integrative approaches in basic and clinical immunology, immunoinformatics, and immunologically relevant instrumentation and high-throughput screening methods.
Immunoinformatics utilizes mathematics, information science, computer engineering, genomics, proteomics and immunological methods to bridge immunology and informatics. Ten expert reviews introduce bioinformaticians and immunologists alike to successfully applied data-driven strategies in MHC, TCR, peptide-MHC and allergen research, epitope prediction, de-immunization of therapeutic proteins, host-pathogen interactions, modeling of immune responses to pathogens and large-scale chemical mutagenesis-driven genetic analyses systems. In contrast to existing books on immunoinformatics which emphasize epitope prediction this volume presents a cross-section of immunoinformatic research. The contributions show the interdisciplinarity of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies towards understanding the immune system.
Immunoinformatics is an ideal volume for scientists, researchers, students and professionals in the fields of Immunology, bioinformatics, microbiology, genetics, systems biology, biotechnology, computational biology.

Download

Mirror

Osteoimmunology: Interactions of the Immune and Skeletal Systems

Osteoimmunology: Interactions of the Immune and Skeletal Systems (Advances in Experimental Medicine and Biology)
by Yongwon Choi (Editor)

Product Details
Hardcover: 156 pages
Publisher: Springer; 1 edition (October 1, 2007)
Language: English
ISBN-10: 0387720081

Book Description
A Key Regulator of Postnatal Skeletal Remodeling.- Ectodomain Shedding of Receptor Activator of NF-KB Ligand.- The Negative Role Of Ids In Osteoclastogenesis.- Functional Genetic and Genomic Analysis of Modeled Arthritis.- Dexamethsone Suppresses Bone Formation via the Osteoclast.- Immunologic Regulation Of Bone Development.- Pth Regulates The Hematopoietic Stem Cell Niche In Bone.- Regulation Of Hematopoietic Stem Cells In The Osteoblastic Niche.- The Chemokine Cxcl12 And Regulation Of Hsc And Lymphocyte Development In The Bone Marrow Niche.- Osteoclast Precursor Cells.- Interaction with estrogen receptors as treatment of arthritis and osteoporosis.- Novel Signaling Pathways And Therapeutic Targets In Osteoclasts.- The Enigmatic Function of TREM-2 in Osteoclastogenesis.- Role of cell-matrix interactions in osteoclast differentiation.- Positive and negative roles of IL-6, STAT3 and SOCS3 in inflammatory arthritis.- Control of Osteoclast activity and bone loss by IKK subunits: new targets for therapy.- Targeting Osteoporosis And Rheumatoid Arthritis By Active Vaccination Against Rankl.- RANKL Inhibition: From Mice to Men (and Women).

Download

Mirror

Mucosal Immune Defense: Immunoglobulin A

Mucosal Immune Defense: Immunoglobulin A
by Charlotte S. Kaetzel (Editor)

Product Details
Hardcover: 433 pages
Publisher: Springer; 1 edition (October 4, 2007)
Language: English
ISBN-10: 0387722319

Book Description
Immune responses at mucosal surfaces play a major role in host mucosal defense against microbial pathogens and in the pathogenesis of acute and chronic mucosal inflammatory diseases. This volume draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches in combination with human and murine in vitro cell culture and in vivo model systems to address questions in mucosal immunity.
Humans produce more immunoglobulin A (IgA) than all other antibody isotypes combined, most of which is rapidly transported into the external secretions bathing mucous membranes. It has been estimated that more than 3 grams of IgA are transported daily into mucosal secretions, carrying out a wide range of antimicrobial and anti-inflammatory functions. IgA is the second most abundant class of antibody in the bloodstream, contributing to systemic as well as secretory immunity. Recent advances in human genomics, gene regulation, structural biology, cell signaling, and immunobiology have greatly enhanced our understanding of this important class of antibody. This book is designed to serve as a concise reference of the present knowledge of the biology of IgA, including structure of IgA and its interaction with Fc receptors; epithelial transport of IgA; regulation of the mucosal IgA system; biological roles of IgA, including newly discovered functions; IgA-associated diseases, and therapeutic applications for IgA. Chapters have been contributed by internationally recognized leaders in the field of IgA research, representing 8 countries on 3 continents.

Download

Mirror

Arachaea: Ancient Microbes, Extreme Environments, and the Origin of Lif

Arachaea: Ancient Microbes, Extreme Environments, and the Origin of Life (Advances in Applied Microbiology, Volume 50)
by Paul Blum (Editor)

Product Details
Hardcover: 382 pages
Publisher: Academic Press; 1 edition (October 2001)
Language: English
ISBN-10: 0120026503

Book Description:
Although they comprise one of the three fundamental branches of life, it was only the last decade that Archaea were formally recognized as a group alongside Eukaryotes and Bacteria. Bacteria-like in that they are single celled organisms that lack a nucleus and intracellular organelles, the Arachaea also share a large gene set typical of eukaryotes, for making and repairing DNA, RNA and protien. More surprisingly, they only inhabit environments typical of the extremes of early earth--hot springs, thermal ocean vents, saline lake, or oxygen deficient sediments. A breakpoint on the common evolutionary path, it is evident that the Archaea diverged early in the history of life, establishing thier importance in evolutionary sciences. Archaea: Ancient Microbes, Extreme Environments, and the Origin of Life tells this evolving story, furthering our understanding of the microbe commonalities, and providing for evolutionary justification in the use of archaea as mechanistic model systems.

Download

Advances in Applied Microbiology, Voume 49

Advances in Applied Microbiology, Voume 49 (Advances in Applied Microbiology)
by Allen I. Laskin (Editor), Geoffrey M. Gadd

Product Details
Hardcover: 196 pages
Publisher: Academic Press; 1 edition (October 2001)
Language: English
ISBN-10: 012002649X

Download

Advances in Applied Microbiology, Volume 4

Advances in Applied Microbiology, Volume 48 (Advances in Applied Microbiology)
by Allen I. Laskin (Editor), Geoffrey M. Gadd (Editor)

Product Details
Hardcover: 225 pages
Publisher: Academic Press; 1 edition (October 2001)
Language: English
ISBN-10: 0120026481

Download

Advances in Applied Microbiology, Volume 47

Advances in Applied Microbiology, Volume 47 (Advances in Applied Microbiology)\
by Saul L. Neidleman (Series Editor), Allen I. Laskin (Series Editor), Joan W. Bennett (Series Editor), Geoffrey M. Gadd (Series Editor)

Product Details
Hardcover: 382 pages
Publisher: Academic Press; 1 edition (October 2000)
Language: English
ISBN-10: 0120026473

Book Description
Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive.

Download

Advances in Applied Microbiology, Volume 60

Advances in Applied Microbiology, Volume 60 (Advances in Applied Microbiology)
by Allen I. Laskin (Series Editor), Sima Sariaslani (Series Editor), Geoffrey M. Gadd

Product Details
Hardcover: 224 pages
Publisher: Academic Press; 1 edition (November 15, 2006)
Language: English
ISBN-10: 0120026627

Book Description
Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in Microbiology.
The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.
Eclectic volumes are supplemented by thematic volumes on various topics including Archaea and Sick Building Syndrome.
Impact factor for 2003: 1.893

Download

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, Volume 2

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, Volume 2: Molecular Pathology, Colorectal Carcinoma, and Prostate Carcinoma
by M. A. Hayat (Editor)

Product Details
* Hardcover: 492 pages
* Publisher: Academic Press; 1 edition (January 12, 2005)
* Language: English
* ISBN-10: 0123339421

Book Description
Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.
This book is the second volume of three planned, individually-sold volumes on this topic. Like Volume 1, this book fully explains the principles and applications of modern techniques used in the field of molecular genetics. It will be of particular interest to pathologists and molecular pathologists conducting both academic and/or clinical research.
* The only book available that translates molecular genetics into cancer diagnosis
* The results of each Immunohistochemical and in situ hybridization method are presented in the form of color illustrations
* Methods discussed were either developed or refined by expert contributors in their own laboratories.

Download

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, Volume 1

Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas, Volume 1: Molecular Genetics; Lung and Breast Carcinomas
by M. A. Hayat (Editor)

Product Details
* Hardcover: 556 pages
* Publisher: Academic Press; 1 edition (May 11, 2004)
* Language: English
* ISBN-10: 0123339413

Book Description
The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by
immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book.
* The only book available that translates molecular genetics into cancer diagnosis
* Provides the readers with tools necessary to perform and optimize sensitive, powerful techniques, including immunohistochemistry and fluorescence in situ hybridization, used in tumor diagnosis
* Written by experts in this field, the book provides theoretical considerations as well as practical approaches to carry out effectively these techniques
* Offers suggestions, tips, cautions, and guidelines to avoid artifacts and misdiagnosis
* Introduces new techniques to detect genes and proteins involved in the initiation and progression of cancer
* Covers the latest developments and a wide range of applications to the detection of antigens and single-copy DNA and RNA
* Written in a uniform format, each chapter includes Introduction, Materials required, step-by-step detailed Methods, Results, Discussion, and comprehensive up-to-date References.

Download

Cancer Immunotherapy

Cancer Immunotherapy, Volume 90 (Advances in Immunology)
by James Allison (Author), Glen Dranoff (Author)

Product Details
* Hardcover: 400 pages
* Publisher: Academic Press; 1 edition (April 3, 2006)
* Language: English
* ISBN-10: 0120224895

Book Description
For some time immunotherapy has been heralded as a breakthrough approach for cancer treatment. Although the potential of this strategy remains solid, the approach needs considerable refinement. Whilst some programmes are looking to increase the understanding of molecular and cellular mechanisms underlying the stimulation of antitumor immunity, others are trying to find the most appropriate clinical setting that will reveal the role of the immune system in combating cancer. Among the most important discoveries have been tumor-specific antigens.
This thematic volume highlights some key issues and discusses where they may move forward. It has been put together by two leading cancer immunotherapists from two eminent institutions that focus on cancer research.

Download

Microbiology of Extreme Soils

Microbiology of Extreme Soils (Soil Biology)
by J.D. Rummel (Foreword), Patrice Dion (Editor), Chandra Shekhar Nautiyal (Editor)

Product Details
Hardcover: 370 pages
Publisher: Springer; 1 edition (December 18, 2007)
Language: English
ISBN-10: 3540742301

Book Description
This volume provides a comprehensive coverage of the principal extreme soil ecosystems of natural and anthropogenic origin. Extreme soils oppose chemical or physical limits to colonization by most soil organisms and present the microbiologist with exciting opportunities.
Described here are fascinating environments, such as permafrost, saline, arid and geothermal soils, peatlands, subsurface geomaterial rich in sulfidic ore, Martian soils, hydrocarbon-contaminated hot desert and Antarctic soils, as well as fire-impacted, heavy-metal and radionuclide contaminated soils. Those environments lend themselves both to timely descriptions of colonizing organisms and their activities, and to thoughtful examination of community structure and microbial evolution. Extreme soils provide invaluable examples of microbial adaptations in coping with hostile habitats. Being home to a remarkable diversity, they are ideal models for scientific exploration and propose solutions to biotechnology and bioremediation challenges.

Download

Mirror

Parasites And Allergy

Parasites And Allergy (Chemical Immunology)
by Monique Capron (Editor), Francois Trottein (Editor)

Product Details
Hardcover: 201 pages
Publisher: Not Avail; 1 edition (January 30, 2006)
Language: English
ISBN-10: 3805579748

Book Description
Universite de Lille 2, France. Text presents contributions to new directions of research for successful immunization against helminths and the prevention of inflammatory responses in allergic and autoimmune diseases. Topics include the mutual influence of nematode infection and allergy, and more. For researchers.

Download

Mirror

Alicyclobacillus: Thermophilic Acidophilic Bacilli

Alicyclobacillus: Thermophilic Acidophilic Bacilli
by A. Yokota (Editor), T. Fujii (Editor), K. Goto (Editor)

Product Details
Hardcover: 259 pages
Publisher: Springer; 1 edition (April 18, 2007)
Language: English
ISBN-10: 4431698493

Book Description
Thermophilic acidophilic spore-forming bacteria Alicyclobacillus can grow at low pH and at moderately high temperatures such as 40°C. Some of the species are known to cause spoilage of acidic beverages and produce medicinal odors. However, they do not produce gas or cause any change in the appearance of the beverage container, and therefore the spoilage is discovered only when the consumer opens and begins to consume the product. Fortunately, Alicyclobacillus are not pathogenic bacteria, but they are troublesome, not only for consumers but also for beverage producers, because no effective control methods have yet been developed. It is against this background and in recognition of the importance and urgency of the problem that International Life Sciences Institute (ILSI) Japan has published this book, bringing together new insights on the topic together with research published to date

Download

Mirror

ABC Proteins: From Bacteria to Man

ABC Proteins: From Bacteria to Man
by I Barry Holland (Editor), Susan P. C. Cole (Editor), Karl Kuchler (Editor), Christopher F. Higgins (Editor)

Product Details
Hardcover: 672 pages
Publisher: Academic Press; 1 edition (December 2002)
Language: English
ISBN-10: 0123525519

Book Description:
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.

Download

Mirror

Origin and Evolution of Viruses

Origin and Evolution of Viruses
by Esteban Domingo (Editor), Robert G. Webster (Editor), John F. Holland (Editor)

Product Details
Hardcover: 499 pages
Publisher: Academic Press; 1st edition (January 15, 1999)
Language: English
ISBN-10: 0122203607

Book Description
"... this book... is a detailed account of current thinking on virus evolution... Because of the diversity of subjects, this book gives an up to date picture of research in various fields of virology, and helps to tease out connections between these fields. the subjects covered are essential reading for virologists but also have direct relevance for molecular biologists, and indeed any researchers with interests in early evolution... This publication is highly recommended for its breadth of coverage and detailed treatments of the various subjects"

Download

Mirror