Electroporation Protocols for Microorganisms

Electroporation Protocols for Microorganisms (Methods in Molecular Biology
by JAC A., ED. NICKOLOFF (Author)

Product Details:
* Spiral-bound: 372 pages
* Publisher: Humana Press; 1st edition (August 15, 1995)
* Language: English
* ISBN-10: 0896033104

Book Description
Electroporation Protocols for Microorganisms is the first complete guide to the electroporation of nearly all microorganisms of importance used in biological and biomedical research. It includes reproducible protocols for diverse bacterial, fungal, and protist species-many of which are important in human disease-as well as literature references to electroporation protocols for related species. The contributors also discuss electroporation theory and instrumentation, making it possible to develop new protocols or modify existing ones, and they provide extensive details about culturing and storing many species in a manner designed to optimize electroporation efficiency.
Electroporation Protocols for Microorganisms is an indispensable resource for molecular geneticists working directly with microorganisms and for those who employ microorganisms to prepare materials for later introduction into higher organisms, such as plants and animals. Two companion volumes will follow: Plant Cell Electroporation and Electrofusion Protocols and Animal Cell Electroporation and Electrofusion Protocols.

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Microorganisms in Plant Conservation and Biodiversity

Microorganisms in Plant Conservation and Biodiversity
by K. Sivasithamparam (Editor), K.W. Dixon (Editor), R.L. Barrett (Editor)

Product Details:
* Hardcover: 392 pages
* Publisher: Springer; 1 edition (December 31, 1899)
* Language: English
* ISBN-10: 1402007809

Book Description

Plant conservation is increasingly recognised as an outstanding global priority, yet despite considerable efforts over the last few decades, the number of threatened species continues to rise. The practice of plant conservation has for too long been a rather hit-or-miss mixture of methods. While microorganisms have been recognised as a crucial and essential element in supporting the lifecycles of plant species, there has been limited recognition of the relationships between macro level conservation facilitating ecosystem functioning at the micro level.
This book addresses the role of microorganisms in conservation - both their support functions and deleterious roles in ecosystem processes and species survival. Importantly, a number of authors highlight how microbial diversity is, itself, now under threat from the many and pervasive influences of man. What is clear from this volume is that like many contemporary treatments of plant and animal conservation, the solution to mitigate the erosion of biodiversity is not simple. This book represents an attempt to bring to the fore the ecological underwriting provided by microorganisms.

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Foodborne Disease Handbook, Volume 1: Bacterial Pathogens

Foodborne Disease Handbook, Volume 1: Bacterial Pathogens
by Y.H. Hui (Author)

Product Details:
* Hardcover: 677 pages
* Publisher: Dekker/CRC Press; 2nd edition (January 15, 2001)
* Language: English
* ISBN-10: 0824703375

Book Description:
Contains new chapters on the role of U. S. poison centers in bacterial exposures; bacteria biota in foods; salmonellosis in animals; human salmonellosis; vibro cholerae; vibrio vulnificus; and more.

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Foodborne Disease Handbook, Volume 2: Viruses, Parasites, Pathogens

Foodborne Disease Handbook, Volume 2: Viruses, Parasites, Pathogens, and HACCP
by Y.H. Hui (Author)

Product Details:
* Hardcover: 515 pages
* Publisher: Dekker/CRC Press; 2nd edition (January 15, 2001)
* Language: English
* ISBN-10: 0824703383

Book Description:
A study of foodborne disease, focusing on viruses, parasites, pathogens and HACCP. This second edition contains new chapters on the role of US poison centres in viral exposures, detection of human enteric viruses in foods, environmental consideration in preventing foodborne spread of hepatitis A, seafood parasites, HACCP principles and control programmes for foodservice operations, and more.

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Foodborne Disease Handbook, Volume 3: Plant Toxicants

Foodborne Disease Handbook, Volume 3: Plant Toxicants
by Y.H. Hui (Author)

Product Details:
* Hardcover: 836 pages
* Publisher: Dekker/CRC Press; 2nd edition (January 15, 2001)
* Language: English
* ISBN-10: 082470343X

Book Description:
A study of foodborne disease, focusing on plant toxicants. This second edition contains new chapters on poison centre management of exposures to plant and mushroom toxins; medical management of plant poisoning; prevention and management of plant toxicants in livestock; Clavicepis; mushroom biology, epidemiology, poisoning and medical management; fungi in folk medicine; and more.

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Foodborne Disease Handbook, Volume 4: Seafood and Environmental Toxins

Foodborne Disease Handbook, Volume 4: Seafood and Environmental Toxins
by Y.H. Hui (Author)

Product Details:
* Hardcover: 660 pages
* Publisher: Dekker/CRC Press; 2nd edition (January 15, 2001)
* Language: English
* ISBN-10: 0824703448

Book Description:
A study of foodborne disease, focusing on seafood and environmental toxins. This second edition discusses fish, shellfish, and freshwater and marine organisms affected by agricultural and food processing products, including raw sewage, industrial effluents, trash and garbage, pesticide runoff from crop lands and top soils, and more.

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Epstein-barr Virus Protocols

Epstein-barr Virus Protocols (Methods in Molecular Biology)
by Joanna, Ed. Wilson (Author)

Product Details:
* Hardcover: 438 pages
* Publisher: Humana Press; 1 edition (March 15, 2001)
* Language: English
* ISBN-10: 0896036901

Book Description
Joanna Wilson and Gerhard May have assembled a collection of the key molecular biology protocols used in the analysis of Epstein-Barr virus (EBV), along with a series of valuable immunology, cell biology, and transgenic mouse protocols. These readily reproducible techniques include methods for gene expression with mini-EBV plasmids, for expression analysis by FISH, for EBV detection and quantitation, and for cell proliferation and death assays. In addition, there are EBV-based vectors, an up-to-date map of EBV, a comprehensive table of available latent protein antisera, and assays from in vitro to cell to organ to organism levels. Timely and highly practical, Epstein-Barr Virus Protocols provides powerful tools for elucidating the life cycle of EBV and its host interactions, work that promises the emergence of major new treatments and cures for EBV associated diseases, including several forms of human cancer.

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Cytokines And Autoimmune Diseases

Cytokines And Autoimmune Diseases
by Vijay K., Ed. Kuchrod (Author)

Product Details:
* Hardcover: 422 pages
* Publisher: Humana Press; 1st edition (January 15, 2002)
* Language: English
* ISBN-10: 0896038564

Book Description
Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

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Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications
by Robert V., Ed. House (Author)

Product Details:
* Hardcover: 366 pages
* Publisher: Humana Press; 1 edition (2007)
* Language: English
* ISBN-10: 1588294676

Book Description

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications. The first section of the book is devoted to basic concepts of cytokine biology, especially as this relates to the practice of immunotoxicology. Chapters in this section review the ability of external influences to modify the expression, production, and activity of these molecules. The second section provides a broad understanding of the range of cytokine activity in human disease, describing methods for assessing cytokine immunotoxicity. In the third and final section of the book, the increasingly important use of cytokines as therapeutics is explored in detail. This section includes examinations into the effects of cytokines on the immune system and in treating cancer. Timely and comprehensive, Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications will serve as both a primer and a starting point for a more detailed investigation of the role these fascinating biological regulators play in human health and disease.

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Modelling microorganisms in food

Modelling microorganisms in food
by S. Brul (Editor), Suzanne van Gerwen (Editor), Marcel Zwietering (Editor)

Product Details:
* Hardcover: 294 pages
* Publisher: CRC; 1 edition (March 19, 2007)
* Language: English
* ISBN-10: 0849391490

Book Description
While predictive microbiology has made a major contribution to food safety, many uncertainties linger, such as the growing evidence that traditional microbial inactivation models do not always fit the experimental data and that all the bacteria of one population do not necessarily behave homogeneously. These problems are all the more acute because of a growing interest in minimal processing techniques that is requiring greater precision from models. Edited by leading authorities, this volume reviews current developments in quantitative microbiology. Part 1 discusses best practice in constructing quantitative models and Part 2 looks at specific areas in new approaches to modelling microbial behavior.

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Glycovirology Protocols (Methods in Molecular Biology

Glycovirology Protocols (Methods in Molecular Biology
by Richard J., Ed. Sugrue (Author)

Product Details:
* Hardcover: 205 pages
* Publisher: Humana Press; 1 edition (2007)
* Language: English
* ISBN-10: 1588295907

Book Description:
This volume reviews the increasing importance of glycosylation to the field of virology, as well as virus replication. The chapters provide an overview of glycosylation in relation to virus infection, and the generic techniques that are used to analyze and characterize glycoproteins.
Among the topics discussed in this volume are M.E. interaction between respiratory syncytial virus and glycosaminoglycans, acute respiratory syndrome coronavirus 3a protein, the C type lectins DC-SIGN and L-SIGN, N-linked glycans, and the use of two-dimensional SDS-PAGE to analyze the glycosylation heterogeneity of the respiratory syncytial virus fusion protein. Also covered in this volume are uses of monoclonal antibodies and lectins, the spike glycoprotein, secretion of respiratory syncytial vius F protein from insect cells, the expression and characterization of recombinant dengue virus E protein, and cloning, expression, and a functional analysis of patient-derived hepatitis C virus glycoproteins.
The information presented in Glycovirology Protocols will provide insight as to how the techniques of glycobiology can be applied in virology and answer most questions that are of interest to the reader.

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Immunological Tolerance: Methods and Protocols

Immunological Tolerance: Methods and Protocols (Methods in Molecular Biology)
by Paul J. Fairchild (Author)

Product Details:
* Hardcover: 611 pages
* Publisher: Humana Press; 1 edition (June 8, 2007)
* Language: English
* ISBN-10: 1588296520

Book Description:
Immunological Tolerance: Methods and Protocols is a comprehensive guide to the techniques currently used for culturing and characterising the cell types responsible for imposing self-tolerance and the experimental models employed to study their function both in vitro and in vivo.

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The Microbial Models of Molecular Biology: From Genes to Genomes

The Microbial Models of Molecular Biology: From Genes to Genomes
by Rowland H. Davis (Author)

Product Details:
* Hardcover: 337 pages
* Publisher: Oxford University Press; 1 edition (2003)
* Language: English
* ISBN-10: 0195154363

Book Description
This book explains the role of simple biological model systems in the growth of molecular biology. Essentially the whole history of molecular biology is presented here, tracing the work in bacteriophages in E. coli, the role of other prokaryotic systems, and also the protozoan and algal models - Paramecium and Chlamydomonas, primarily - and the move into eukaryotes with the fungal systems - Neurospora, Aspergillus and yeast. Each model was selected for its appropriateness for asking a given class of questions, and each spawned its own community of investigators. Some individuals made the transition to a new model over time, and remnant communities of investigators continue to pursue questions in all these models, as the cutting edge of molecular biological research flowed onward from model to model, and onward into higher organisms and, ultimately, mouse and man.

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Inmunologia En Esquemas (Spanish)

Inmunologia En Esquemas - 6b: Edicion (Spanish)
by John H. L. Playfair (Author)

Product Details:
* Paperback
* Publisher: CTM Servicios Biblio (November 1997)
* Language: Spanish
* ISBN-10: 959665022X

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Cytokines and Chemokines in Infectious Diseases Handbook

Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease)
by Malak Kotb (Editor), Thierry Calandra (Editor)

Product Details:
* Hardcover: 456 pages
* Publisher: Humana Press; 1 edition (March 3, 2003)
* Language: English
* ISBN-10: 0896039080

Book Description
A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

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Morphology Methods: Cell and Molecular Biology Techniques

Morphology Methods: Cell and Molecular Biology Techniques
by Ricardo V. Lloyd (Editor)

Product Details:
* Hardcover: 422 pages
* Publisher: Humana Press; 1st edition (June 15, 2001)
* Language: English
* ISBN-10: 0896039552

Book Description
Ricardo Lloyd, md, phd, provides critical and tutorial surveys of the cutting-edge molecular and cell biologic techniques used today in the analysis of cells and tissues in situ. These molecular-based histologic and morphologic techniques are described in step-by-step detail by hands-on experts, often those who have originated or perfected them. Among the techniques presented are laser capture microdissection, in situ hybridization, FISH, confocal laser scanning microscopy, in situ PCR, and tyramide amplification. Applications include the detection of infectious agents and DNA, the diagnosis of undifferentiated tumors and endocrine lesions, the metaphase analysis of whole blood cultures, and clonality analysis. In its integrated, state-of-the-art approach, Morphology Methods: Cell and Molecular Biology Techniques thoroughly details and applies the rich panoply of significant new cell and molecular biologic technologies to all the major problems confronting morphologic studies and diagnostic pathology today.

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Xenotransplantation: Basic Research and Clinical Applications

Xenotransplantation: Basic Research and Clinical Applications
by Jeffrey L. Platt (Editor)

Product Details;
* Hardcover: 270 pages
* Publisher: Humana Press; 1st edition (May 15, 2002)
* Language: English
* ISBN-10: 089603674X

Book Description
Internationally recognized scientists, clinicians, and technologists review and explain the fundamental molecular and cellular biology that has been applied to the emerging field of transplant immunology and xenotransplantation, and what impact these advances might optimally have on medicine and science. The authoritative experts writing here-many of whom made the basic discoveries underlying the recent advances-examine the biological and immunological hurdles to xenotransplantation, illuminating how the immune system interacts with the xenograft and laying a practical foundation for the use of genetic engineering and animal transplants in the treatment of human disease.

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Mycobacterium tuberculosis Protocols

Mycobacterium Tuberculosis Protocols (Methods in Molecular Medicine)
by Tanya Parish (Editor), Neil G. Stoker (Editor)

Product Details:
* Hardcover: 424 pages
* Publisher: Humana Press; 1 edition (February 15, 2001)
* Language: English
* ISBN-10: 0896037762

Book Description
Leading investigators with extensive practical knowledge and experience describe their best methods for studying the tuberculosis pathogen. Packed with step-by-step instructions to ensure successful results, these methods range from basic handling techniques to the application of functional genomics. Highlights include methods for the basic safety and culture of M. tuberculosis, fractionation of the bacterium (nucleic acids, lipids, culture filtrate, and capsule), the analysis of gene expression (start site mapping, real-time PCR microarrays, and proteomics), the growth of the bacterium in macrophages and low oxygen, cytological analysis of the bacteria, and diagnostics. Highly practical and accessible, Mycobacterium tuberculosis Protocols utilizes advanced functional genomics and mutagenesis methodologies to provide both experimental and clinical investigators all the powerful techniques needed to illuminate the molecular biology of tuberculosis and its interactions with host cells, and so drive work on the wide variety of emerging therapeutic opportunities.

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Microbial DNA and Host Immunity

Microbial DNA and Host Immunity
by Eyal, Ed. Raz (Author)

Product Details:
* Hardcover: 408 pages
* Publisher: Humana Press; 1st edition (June 15, 2002)
* Language: English
* ISBN-10: 1588290220

Book Description
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).

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Combating the Threat of Pandemic Influenza: Drug Discovery Approaches

Combating the Threat of Pandemic Influenza: Drug Discovery Approaches
by Paul F. Torrence (Editor)

Product Details:
* Hardcover: 296 pages
* Publisher: Wiley-Interscience; 1 edition (October 5, 2007)
* Language: English
* ISBN-10: 0470118792

Book Description
This book discusses promising antiviral drug discovery strategies. All researchers in medicinal chemistry, pharmaceutical chemistry, drug discovery, biochemistry, virology, microbiology, and public health will find this book of great use and importance. This publication provides guidance on developing drugs to protect the health of the world against the threat of emerging infectious diseases and bioterrorism.

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Practical Immunopathology of the Skin

Practical Immunopathology of the Skin (CURRENT CLINICAL PATHOLOGY)
by Bruce R. Smoller (Author)

Product Details:
* Hardcover: 208 pages
* Publisher: Humana Press, Inc.; 1 edition (September 2, 2002)
* Language: English
* ISBN-10: 1588291499

Book Description
Bruce R. Smoller, md, concisely reviews for practitioners and students alike the science of immunopathology, its many basic laboratory tools, and their multiple diagnostic uses in actual clinical case studies. The author presents in an easily digestible form a dictionary of antibody probes, summarizing for each antibody the targeted antigen and its cellular function, its diagnostic utility, and, when available, its sensitivities and specificities for identifying various neoplasms. Real clinical cases from the author's practice demonstrate the benefits of immunopathology.

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Atomic Force Microscopy in Cell Biology

Atomic Force Microscopy in Cell Biology (Methods in Cell Biology, Volume 68)
by Bhanu P. Jena (Editor), J.K. Heinrich Horber (Editor), Leslie Wilson (Series Editor), Paul T. Matsudaira (Series Editor)

Product Details;
* Paperback: 415 pages
* Publisher: Academic Press; 1st edition (May 2002)
* Language: English
* ISBN-10: 0123838517

Book Description
This is the first book to cover the history, structure, and application of atomic force microscopy in cell biology. Presented in the clear, well-illustrated style of the Methods in Cell Biology series, it introduces the atomic force microscope (AFM) to its readers and enables them to tap the power and scope of this technology to further their own research. A practical laboratory guide for use of the atomic force and photonic force microscopes, it provides updated technology and methods in force spectroscopy. It is also a comprehensive and easy-to-follow practical laboratory guide for the use of the AFM and PFM in biological research.

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Prebiotics: Development and Application

Prebiotics: Development and Application
by Bob Rastall (Editor), Glenn Gibson (Editor)

Product Details:
* Hardcover: 264 pages
* Publisher: Wiley (June 5, 2006)
* Language: English
* ISBN-10: 0470023139

Book Description
The prebiotic concept works on the basis that many potentially health-promoting microorganisms are already present in humans. Prebiotics are non-digestible food ingredients that stimulate activity in targeted microorganisms, to improve the health of the individual. Prebiotics can be incorporated into many foodstuffs such as beverages, health and sports drinks, infant formulae, cereals, bread, savoury products and so forth, and are receiving much commercial interest.
Prebiotics: Development and Application is the first book to consolidate research in this emerging area of ‘functional food’ study. The book takes a broad view approach to prebiotics, from the conceptual stage, definition, production, evaluation of individual food products and their effect on microbial flora, and their potential relation to diseases.
The book starts with an introduction to the prebiotic concept and its development, proceeds to consider the synthesis and manufacture of prebiotics and testing for prebiotic effects, and will then consider different forms of prebiotics (e.g. fructans, galactans, lactulose etc). The book will then look at prebiotic intervention for improving human health (acute and chronic disorders) and animal health. The book closes by considering the sectors for prebiotic foods, development and commercialisation issues, and future developments.

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Virology: Principles and Applications

Virology: Principles and Applications
by John Carter (Author)

Product Details:
* Paperback: 358 pages
* Publisher: John Wiley & Sons; 1 edition (2007)
* Language: English
* ISBN-10: 0470023872

Book Description
Virology: Principles and Applications is a clear and accessible introduction to this fast-moving field, providing a comprehensive resource enabling the reader to understand the key concepts surrounding this exciting subject. The reader is introduced to the principles of virus structure, replication and genetics, along with the theories behind the origins of viruses and how they are evolving. Taking a modern approach to the subject, the relevance of virology to everyday life is clearly emphasised and discussions of emerging viruses, cancer, vaccines, anti-viral drugs and gene vectors are included. To enhance student understanding, learning outcomes, sources of further information and ‘at-a-glance’ sections are integrated into in each chapter, reinforcing key concepts.

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Therapeutic Uses of Botulinum Toxin

Therapeutic Uses of Botulinum Toxin
by Grant Cooper (Editor)

Product Details:
* Hardcover: 242 pages
* Publisher: Humana Press; 1 edition (June 13, 2007)
* Language: English
* ISBN-10: 1588299147

Book Description
Therapeutic Uses of Botulinum Toxin outlines and examines our current understanding of botulinum toxin and its various therapeutic applications. The editors explore how this novel compound fits into a wide variety of treatment algorithms across medical subspecialties. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. The chapter authors are all leaders in their fields and are respected for their progressive approach to treatment. Physicians will benefit not only from those chapters devoted to their particular sub-specialty, but from the inspiring success resulting from the use of botulinum toxin in other patient populations. The concluding chapter examines questions of immunity, explores economic issues, and attempts to forecast future directions for this novel and somewhat mysterious drug. Clinicians across a wide variety of disciplines will refer to this comprehensive reference time and time again.

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Aging, Immunity, and Infection

Aging, Immunity, and Infection (Infectious Disease)
by Joseph F. Albright (Author), Julia W. Albright (Author)

Product Details:
* Hardcover: 256 pages
* Publisher: Humana Press; 1 edition (January 15, 2003)
* Language: English
* ISBN-10: 0896036448

Book Description
Two prominent immunogerontologists review the major features and functions of the immune system that are most likely, or known, to be significantly altered by aging, and offer insightful analyses of the consequences for those aging subjects who must cope with infection. Topics of special interest include the demographics and theories of immunosenescence, the gradual breakdown of resistance to infection in the aged, and the effects of aging on selected mechanisms of both innate and adaptive immunity to infections. The Albrights also explain how advances may be made in understanding the basic biology, the newer methods of treatment and prevention, and the evaluation of such provocative ideas as lifespan extension and nutritional intervention to delay immunosenescence.

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Clinical Applications of PCR

Clinical Applications of PCR (Methods in Molecular Biology)
by Y.M. Dennis Lo (Author), W.K. Chiu Rossa (Author), Allen Chan (Author)

Product details:
* Hardcover: 216 pages
* Publisher: Humana Press Inc.,U.S.; 2Rev Ed edition (Mar 2006)
* Language English
* ISBN-10: 1588293483

Book Description
In this updated second edition, leading researchers apply molecular diagnostics to the many recent advances that have occurred in polymerase chain reaction(PCR)-based technologies. Highlights include real-time PCR, which allows the technique to be performed in a quantitative manner with improved sensitivity, robustness, and resilience to carry over contamination, mass spectrometric analysis of nucleic acids, and circulating cell-free nucleic acids in plasma. The authors apply these innovations to a broad spectrum of applications, including gene expression, methylation, trace molecule, gene dosage, and single cell analysis.

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Current Topics in Innate Immunity

Current Topics in Innate Immunity (Advances in Experimental Medicine and Biology)
by John D., Ed. Lambris (Author)

Product Details:
* Hardcover: 438 pages
* Publisher: Springer; 1 edition (August 22, 2007)
* Language: English
* ISBN-10: 038771765X

Book Description
Innate Immunity has long been regarded as the non-specific arm of immune response, acting immediately and in a generic way, to defend the host from infections. In the post genomic era, our knowledge of the innate immune system is enriched by findings on the specificity of innate immune reactions as well as to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or inflammation. Several studies indicate that molecules involved in innate immunity exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system.
The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led scientists to revisit established biological systems from a global and integrative perspective. Innate Immunity research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the 4th International Conference on Innate Immunity (June 4 - 9, 2006), in Corfu, Greece to discuss recent advances in this fast evolving field.
This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.

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Cryopreservation and Freeze-Drying Protocols

Cryopreservation and Freeze-Drying Protocols (Methods in Molecular Biology)
by John G. Day (Editor), Glyn N. Stacey (Editor)

Product Details:
* Hardcover: 348 pages
* Publisher: Humana Press; 2nd ed. edition (June 5, 2007)
* Language: English
* ISBN-10: 1588293777

Book Description
Cryopreservation and Freeze-Drying Protocols: Second Edition is a compilation of robust, reproducible techniques for the conservation of a wide range of biological materials. This widely expanded second edition includes novel approaches and protocols for biological materials that were not preservable when the first edition was published in 1995.
This volume begins with a discussion of long term ex situ conservation of biological resources, the role of biological resource centers, and fundamental principles of freeze-drying and cryopreservation. Each chapter focuses on the preservation of specific biological materials, including proteins, mircroorganisms, cell lines, and multicellular structures. Detailed descriptions of materials required and stepwise protocols are presented for each preservation method, along with explanatory notes that highlight key technical issues. The troubleshooting and background notes provided for each protocol enhance this practical and reliable resource for the conservation and sustainable use of biological resources.

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Halophilic Microorganisms and their Environments

Halophilic Microorganisms and their Environments (Cellular Origin, Life in Extreme Habitats and Astrobiology)
by A. Oren (Author)

Product Details:
* Hardcover: 600 pages
* Publisher: Springer; 1 edition (August 31, 2002)
* Language: English
* ISBN-10: 1402008295

Book Description
The halophilic microorganisms form a highly diverse group of organisms. They present the biochemist/physiologist with interesting questions on the strategies used to cope with high osmotic pressures exerted by hypersaline brines. They often have a strong impact on the ecosystems in which they thrive. The first section of the book presents in-depth discussions of the taxonomy, cellular properties, metabolic diversity, pigments, ion metabolism and organic osmotic solutes, properties of halophilic proteins, genetics, and biotechnological uses of halophilic microorganisms. The second section describes the occurrence and functioning of these organisms in the Great Salt Lake, the Dead Sea, solar saltern ponds, alkaline soda lakes, and other hypersaline environments worldwide. Each chapter contains an extensive list of references. No other book provides in-depth up-to-date coverage of all subjects described. The volume is intended for researchers and students interested in microbial physiology, microbial ecology, environmental sciences, and extremophilic biotechnology.

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Disinfection and Decontamination: Principles, Applications and Related Issues

Disinfection and Decontamination: Principles, Applications and Related Issues
by Manivannan (Author)

Product Details:
* Hardcover: 512 pages
* Publisher: CRC Press; 1 edition (October 2007)
* Language: English
* ISBN-10: 0849390745

Book Description

In the battle between humans and microbes, knowledge may be not only the best weapon but also the best defense. Pulling contributions from 34 experts into a unified presentation, Disinfection and Decontamination: Principles, Applications, and Related Issues provides coverage that is both sophisticated and practical. The book reviews the fundamentals, explores the interdisciplinary nature of the science, and includes discussions of regulatory and legal issues. While the chapters present in depth coverage of infections in hospitals, they also widen their scope to include laboratories outside the healthcare environment. Based on practical experience, the volume examines recent advances in the research, development, and applications for disinfection and decontamination in many different settings. The chapters address, and supply insight into, the issues found with infectious disease, devices and new materials for implantation, principles, mechanisms, testing methods and strategies, and various applications. They also cover current research and best practice for ways to reduce infection caused by devices. The book's emphasis on new technologies highlights the need for safer biocides and microbiological concerns in the manufacturing environment. The broad focus combined with the global, interdisciplinary panel of authors gives you a snapshot of disease transmission, perspectives on infectious challenges and solutions in a global perspective, and an understanding of global governance. The book offers in depth information on specific topics and an understanding of the fundamentals, giving you a starting point and precise information for resolving problems.

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Chemokines and Cancer

Chemokines and Cancer (Contemporary Cancer Research)
by Barrett Rollins (Editor)

Product Details:
* Hardcover: 336 pages
* Publisher: Humana Press; 1 edition (April 9, 1999)
* Language: English
* ISBN-10: 089603562X

Book Description
Chemokines and Cancer synthesizes a state-of-the-art understanding of the role that chemokines and their receptors play in the pathophysiology of malignancy. It examines the influence of chemokines on a broad array of malignant cells, including their effects on such intrinsic properties as growth and movement, as well as exploring their influence on the host's response to a growing tumor. The authors also demonstrate the physiological consequences of chemokine expression and suggest how chemokines can be used to regulate tumor growth in vivo, including their direct effects on tumor growth, on tumor destruction by host inflammatory cells, and on tumor angiogenesis. The only book available that relates chemokines to cancer, Chemokines and Cancer holds out the promise of novel therapeutic approaches to malignancy through the manipulation of chemokines and/or their receptors.

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Bacterial Genomes and Infectious Diseases

Bacterial Genomes and Infectious Diseases
by V. L. (Ricky) Chan (Editor), Philip M. Sherman (Editor), Billy Bourke (Editor)

Product Details:
* Hardcover: 288 pages
* Publisher: Humana Press; 1 edition (July 8, 2006)
* Language: English
* ISBN-10: 158829496X

Book Description
The emergence and reemergence of infectious diseases, an increasing rate of antibiotic-resistant variants of pathogens, and the threat of bioterrorism underscore the importance of bacterial genomes and infectious diseases. Bacterial Genomes and Infectious Diseases presents major findings about bacterial genomes and their impact on strategy and approach for investigating mechanisms of pathogenesis of infectious diseases. This book imparts fundamental knowledge on the structure, organization, and evolution of bacterial genomes. The value and power of comparative genomics and proteomics, bioinformatics, microarrays, and knockout animal models in analyzing genomes, bacteria-host interactions and disease are demonstrated. Also discussed are the genomes of virulent and nonvirulent strains and species, origin and evolution of pathogens, different models of bacteria-host interactions, and diseases mechanisms.

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Virus-Insect-Plant Interactions

Virus-Insect-Plant Interactions
by Kerry F. Harris (Editor), Oney P. Smith (Editor), James E. Duffus (Editor)

Product Details:
* Hardcover: 376 pages
* Publisher: Academic Press (September 2001)
* Language: English
* ISBN-10: 0123276810

Book Description
In Virus-Insect-Plant Interactions, the world's leading scientists discuss the latest breakthroughs in understanding the biological and ecological factors that define these complex transmission systems and how this knowledge might be used to our advantage in producing innovative, user and environmentally friendly approaches to controlling the spread of plant pathogens by insects. This is an invaluable reference work for researchers, teachers, and students. There are many quick-reference figures and tables, the contents pages include individual chapter abstracts, and each chapter ends with its own bibliography.

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Antigen-Presenting Cells and the Eye

Antigen-Presenting Cells and the Eye
by Manfred Zierhut (Editor), Hans-Georg Rammensee (Editor), Wayne Streilein (Editor)

Product Details:
* Hardcover: 256 pages
* Publisher: Informa Healthcare; 1 edition (July 25, 2007)
* Language: English
* ISBN-10: 0849390206

Book Description
In recent years the importance of antigen-presenting cells and their influence on the eyes has been elucidated. We have learned that nearly every structure of the eye harbors these cells, yet they differ in their activities and thus in the ways in which they protect against - or participate in - diseases of the eye. Antigen-Presenting Cells and the Eye summarizes current knowledge about ACPs in general, and their role in the eye, in particular.

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Brain Tumor Immunotherapy

Brain Tumor Immunotherapy
by Linda M. Liau (Editor), Donald P. Becker (Editor), Timothy F. Cloughesy (Editor), Darell D. Bigner (Editor)

Product Details:
* Hardcover: 373 pages
* Publisher: Humana Press; 1st edition (January 15, 2001)
* Language: English
* ISBN-10: 0896036383


Book Description
An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

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Cytokine Inhibitors

Cytokine Inhibitors
by Gennaro Ciliberto (Editor)

Product Details:
* Hardcover: 372 pages
* Publisher: CRC; 1st edition (January 15, 2001)
* Language: English
* ISBN-10: 0824704347

Book Description:
Compiling an up-to-date and detailed survey of the role cytokines play in cell-to-cell communication, development, and differentiation, this comprehensive reference highlights the medical advantages of cytokine inhibition and pursues novel methods of discovery for more potent and specific blocking agents. Investigates the pathogenic role of cytokines and the potential of cytokine inhibitors as anti-inflammatory, anticancer, antiviral agents! Written by 25 recognized experts revealing recent breakthroughs in research, Cytokine Inhibitors · illustrates cases of naturally produced or in vitro engineered polypeptide cytokine blocking agents · describes all possible approaches to cytokine inhibitors, including monoclonal antibodies, soluble receptors, engineered mutant cytokines, and small-molecular-weight receptor antagonists and signaling inhibitors · clearly explains the homeostatic function of cytokine inhibition and verifies therapeutic approaches effecting natural responses in organisms · discusses the results of clinical trials and therapeutic applications of first-generation recombinant receptor antagonists, such as the potential of tumor necrosis factor antagonists as prominent tools in the therapy of chronic inflammatory conditions · concentrates on the clinical development of second-generation small-molecular-weight, orally bioavailable cytokine inhibitors · reviews the improved understanding of intracellular signaling pathways, the structural determinants responsible for cytokine-receptor interaction · lists the three-dimensional structure, relevant receptors, and intracellular tyrosine kinases of cytokines · and much more! Containing over 1400 references as well as tables and drawings, Cytokine Inhibitors serves as an exemplary reference for basic and clinical immunologists; allergists; biochemists; pathologists, hematologists; experimental, cell, and molecular biologists; rheumatologists; infectious disease specialists; medicinal chemists; and medical school and upper-level undergraduate and graduate students in these disciplines.

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Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance

Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance
by Arch G. Mainous III (Editor), Claire Pomeroy (Editor)

Product Details:
* Hardcover: 350 pages
* Publisher: Humana Press; 1st edition (January 15, 2001)
* Language: English
* ISBN-10: 0896038211

Book Description
Arch Mainous III, PhD, Claire Pomeroy, MD, and a panel of experienced physicians offer an eminently practical summary of the most effective evidence-based antimicrobial treatments encountered in both hospital and outpatient settings. Focusing on the clinical impact of appropriate diagnosis and treatment, the book emphasizes those newer aspects of infectious disease management necessitated by the growing problem of antibiotic resistance. It also discusses the major pathogens involved so that practicing clinicians will not only diagnose, but also better treat the infections and complications they cause. Multidisciplinary and highly practical, Management of Antimicrobials in Infectious Diseases: Impact of Antibiotic Resistance offers busy clinicians and nurse practitioners a comprehensive and informed guide to navigating the difficult treatment decisions created by the rising tide of antibiotic resistance today.

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Gene Delivery to Mammalian Cells: Volume 2: Viral Gene Transfer Techniques

Gene Delivery to Mammalian Cells: Volume 2: Viral Gene Transfer Techniques (Methods in Molecular Biology)
by William C. Heiser (Editor)

Product Details:
* Hardcover: 592 pages
* Publisher: Humana Press; 1 edition (October 28, 2003)
* Language: English
* ISBN-10: 1588290956

Book Description
Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures for delivering genes to cells in vitro and in vivo, including the use of lentiviral vectors. An accompanying volume, Volume 1: Nonviral Gene Transfer Techniques focuses on gene delivery by a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electroporation, particle bombardment, dendrimers, and hydrodynamics.

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Principles of Bacterial Pathogenesis

Principles of Bacterial Pathogenesis
by Eduardo A. Groisman (Editor)

Product Details:
* Hardcover: 826 pages
* Publisher: Academic Press; 1st edition (December 2000)
* Language: English
* ISBN-10: 0123042208

Book Description
Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants.
Key Features
* Explains the basic principles of bacterial pathogenesis
* Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans
* Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors
* Presents authoritative treatises of the major disease microorganisms

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Essentials of Apoptosis: A Guide for Basic and Clinical Research

Essentials of Apoptosis: A Guide for Basic and Clinical Research
by Xiao-Ming Yin (Editor), Zheng Dong (Editor)

Product Details:
* Hardcover: 272 pages
* Publisher: Humana Press; 1 edition (March 7, 2003)
* Language: English
* ISBN-10: 1588291464

Book Description
Basic and clinical investigators systematically compile a comprehensive but concise summary of essential, up-to-date information about apoptosis. The authors present the concepts, the molecular architecture, the biochemical pathways, and the pathophysiological significance of apoptosis. In addition, standard biochemical and cell biologic approaches to apoptosis research are described as a guideline for bench work, with clinical applications detailed for immune disorders, cancer, ischemia/reperfusion injury, and neuronal degeneration.

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Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews

Genomics, Proteomics, and Clinical Bacteriology: Methods and Reviews (Methods in Molecular Biology)
by Neil Woodford (Editor), Alan P. Johnson (Editor)

Product Details:
* Hardcover: 408 pages
* Publisher: Humana Press; 1 edition (May 12, 2004)
* Language: English
* ISBN-10: 1588292185

Book Description
An accessible introduction to how genomics has and will provide novel methods for bacterial investigation and advance our understanding and knowledge of bacterial pathogenicity. The authors critically evaluate the applications of genomics to diagnostic bacteriology, highlighting both current and likely future uses, describing real-time PCR methods, and outlining the promise of microarrays in clinical bacteriology. Their discussion examines in detail genomic approaches to antibacterial discovery, the nature of pathogenicity, the discovery of new pathogens, the exploration of the concept of clonality in bacteria, and bacterial taxonomics.

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Medizinische Mikrobiologie (German)

Medizinische Mikrobiologie
by W. Köhler (Author), H. J. Eggers (Author), B. Fleischer (Author)

Product Details:
* Paperback: 914 pages
* Publisher: Urban & Fischer (January 1, 2001)
* Language: German
* ISBN-10: 3437416405

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Genomics, Proteomics and Vaccines

Genomics, Proteomics and Vaccines
by Guido Grandi (Editor)

Product Details:
* Hardcover: 336 pages
* Publisher: Wiley (March 19, 2004)
* Language: English
* ISBN-10: 0470856165

Book Description
While the sequence of the human genome sequence has hit the headlines, extensive exploitation of this for practical applications is still to come. Genomic and post-genomic technologies applied to viral and bacterial pathogens, which are almost equally important from a scientific perspective, have the potential to be translated into useful products and processes much more rapidly.
Genomics, Proteomics and Vaccines introduces the history of vaccinology and discusses how vaccines are expected to evolve in the future. It describes the relevant technologies, including genome sequencing and analysis, DNA microarrays, 2D electrophoresis and 2D chromatography, mass spectrometry and high-throughput protein expression and purification. The book also features examples of the exploitation of genomics and post-genomics in vaccine discovery, and contains useful descriptions of the biology and pathogenesis of clinically important bacterial pathogens.
This book should be of interest to all those working in vaccine discovery and development in pharmaceutical and biotechnology companies as well as in academic institutions.

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HIV-1: Molecular Biology and Pathogenesis

HIV-1: Molecular Biology and Pathogenesis: Viral Mechanisms, Volume 55, Second Edition (Advances in Pharmacology)
by Kuan-Teh Jeang (Editor), J. Thomas August (Editor), Ferid Murad (Editor)

Product Details:
* Hardcover: 488 pages
* Publisher: Academic Press; 2 edition (June 11, 2007)
* Language: English
* ISBN-10: 01237361

Book Description:
This volume covers the latest advances in the mechanisms of pathogenesis of the HIV-1 virus on target cells. Its companion volume, Advances in Pharmacology 56, shows how new developments in understanding the virus translate to the clinical setting.

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Cytokine Protocols

Cytokine Protocols (Methods in Molecular Biology)
by Marc De Ley (Editor)

Product Details:
* Hardcover: 248 pages
* Publisher: Humana Press; 1 edition (October 8, 2003)
* Language: English
* ISBN-10: 089603948X

Book Description
A collection of biochemical, cellular, and molecular techniques for unraveling and quantifying the events occurring between the initial contact of a cytokine at the membrane receptor and the eventual activation of gene transcription. The techniques used include the generation of transfectants, the immunohistochemical detection of cytokines in tissue sections, and optimized staining for cytoplasmic detection. Highlights include RT-PCR of small amounts of mRNA, in situ hybridization, biosensor analysis, measurement of biological activities and standardization, immunohistochemical and single-cell detection, and receptor isolation, characterization, and crystallization.

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Enzyme Assays

Enzyme Assays: High-throughput Screening, Genetic Selection and Fingerprinting
by Jean-Louis Reymond (Editor)

Product Details:
* Hardcover: 386 pages
* Publisher: Wiley-VCH (March 10, 2006)
* Language: English
* ISBN-10: 3527310959

Book Description
Edited by one of the leading experts in the field, this book fills the need for a book presenting the most important methods for high-throughput screenings and functional characterization of enzymes. It adopts an interdisciplinary approach, making it indispensable for all those involved in this expanding field, and reflects the major advances made over the past few years.
For biochemists, analytical, organic and catalytic chemists, and biotechnologists.

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Diagnostic Bacteriology Protocols

Diagnostic Bacteriology Protocols (Methods in Molecular Biology)
by Louise OConnor (Editor)

Product Details:
* Hardcover: 236 pages
* Publisher: Humana Press; 2 edition (April 21, 2006)
* Language: English
* ISBN-10: 158829594X

Book Description
This fully updated edition includes the novel identification, detection, and typing technologies that are transforming the field of diagnostic testing. The authors, working at the forefront of diagnostic test development, highlight these new technologies and describe current and future molecular diagnostic tests and related nucleic acid extraction methods. The protocols range from advanced molecular detection, quantification, and typing systems, to protocols for diagnostic protein identification, serological testing, and cell culture-based assays. The emphasis is on nucleic acid-based diagnostics and alternative biochemically- and immunologically-based formats that can provide significant potential for multiparameter testing and automation.

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Transplantation Immunology: Methods and Protocols

Transplantation Immunology: Methods and Protocols (Methods in Molecular Biology)
by Philip Hornick (Editor)

Product Details:
* Hardcover: 440 pages
* Publisher: Humana Press; 1 edition (March 1, 2006)
* Language: English
* ISBN-10: 1588295443

Book Description
Leading clinicians and scientists in solid organ transplantation review the current status of the field and describe cutting-edge techniques for detecting the immune response to the allografted organ. The authors present the latest techniques for HLA typing, detecting HLA antibodies, and monitoring T-cell response, and examine more specialized methods utilizing proteomics, laser dissection microscopy, and real-time polymerase chain reaction. The area of tolerance induction and reprogramming of the immune system is also covered, along with a discussion of up-to-date methods of organ preservation, of today's optimal immunosuppressive drug regimens, as well as the difficulty of mimicking chronic rejection in experimental models. Introductory chapters provide a theoretical update on current practices in renal, liver, islet, and lung transplantation and on the pathways of antigen presentation and chronic rejection.

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Integrins

Integrins, Volume 426 (Methods in Enzymology)
by David A. Cheresh (Editor)

Product Details:
* Hardcover: 500 pages
* Publisher: Academic Press (August 27, 2007)
* Language: English
* ISBN-10: 0123739241

Book Description
An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. It plays a role in the attachment of a cell to the extracellular matrix (ECM) and to other cells, and in signal transduction from the ECM to the cell. There are many types of integrin, and many cells have multiple types on their surface. Integrins are of vital importance to all metazoans, from humans to sponges. This volume in Methods in Enzymology presents methods for studying integrins.

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Infectious Causes of Cancer: Targets for Intervention

Infectious Causes of Cancer: Targets for Intervention (Infectious Disease)
by James J. Goedert (Editor)

Product Details:
* Hardcover: 498 pages
* Publisher: Humana Press; 1st edition (April 15, 2000)
* Language: English
* ISBN-10: 089603772

Book Description
James J. Goedert and a team of leading experimental and clinical researchers provide critical, integrating surveys of those viruses, bacteria, and parasites that are now known to play a major role in cancer-work that opens the way toward novel therapeutic targets. The contributors focus on five types of human carcinogenic infection-herpesviruses, retroviruses, papillomaviruses, hepatitis viruses, and H. pylori-and review in depth the associated malignancies, as well as how these new diagnostic and therapeutic technologies may be implemented. Cutting-edge and cross-disciplinary, Infectious Causes of Cancer: Targets for Intervention provides clinical oncologists and infectious disease specialists, as well as clinical researchers, with insightful reviews of cancer induction by infectious diseases and the high promise of closely targeted new therapeutics and vaccines.

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RNA Editing

RNA Editing, Volume 424 (Methods in Enzymology)
by Jonatha Gott (Editor)

Product Details:
* Hardcover: 560 pages
* Publisher: Academic Press; 1 edition (August 6, 2007)
* Language: English
* ISBN-10: 0123739225

Book Description
RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems.

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Infectious Disease in the Aging: A Clinical Handbook

Infectious Disease in the Aging: A Clinical Handbook (Infectious Disease)
by Thomas T. Yoshikawa (Editor)

Product Details:
* Hardcover: 336 pages
* Publisher: Humana Press; 1st edition (January 15, 2001)
* Language: English
* ISBN-10: 0896037444

Book Description
A panel of well known and highly experienced geriatric physicians and infectious disease experts review the most important common infections affecting the elderly and delineate their proven diagnostic, therapeutic, and preventive techniques for dealing with such common organ system problems as urinary tract infections, pneumonia, and ocular infections, as well as such specific microbial infections as tuberculosis, fungal, and viral infections. Also discussed are sepsis, infective endocarditis, intraabdominal infections, bacterial meningitis, osteomyelitis and septic arthritis, and prosthetic device infections. Comprehensive, informative, and easily accessible, Infectious Disease in the Aging: A Clinical Handbook offers all physicians treating geriatric patients today's quickest and most up-to-date guide to the understanding, diagnosis, treatment, and prevention of infectious disease problems in the elderly.

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RNA Interference, Editing, and Modification: Methods and Protocols

RNA Interference, Editing, and Modification: Methods and Protocols (Methods in Molecular Biology)
by Jonatha M. Gott (Editor)

Product Details:
* Hardcover: 456 pages
* Publisher: Humana Press; 1 edition (April 15, 2004)
* Language: English
* ISBN-10: 1588292428

Book Description
A comprehensive collection of cutting-edge methods for elucidating the function of new genes and altering gene expression. These readily reproducible techniques can be used either in transient and stable gene splicing applied to worms, flies, trypanosomes, mammals, and plants, or in studying RNA editing mechanisms in a wide range of organisms, including systems that involve the conversion of one base to another and insertion/deletion editing. Topics of interest include stable and transient RNA interference, gene silencing, RNA editing, bioinformatics, small noncoding RNAs, and RNomics. Special attention is given to methods for the identification and characterization of small RNAs involved in RNA interference or modification.

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Food Microbiology Protocols

Food Microbiology Protocols (Methods in Biotechnology)
by John F. T. Spencer (Editor), Alicia L. Ragout de Spencer (Editor)

Product Details:
* Hardcover: 512 pages
* Publisher: Humana Press; 1st edition (December 12, 2000)
* Language: English
* ISBN-10: 089603867X

Book Description
Expert laboratorians present a wide ranging set of detailed techniques for investigating the nature, products, and extent of the microorganisms involved in the manufacture and spoilage of foodstuff. The methods cover pathogenic organisms that cause spoilage, microorganisms in fermented foods, and microorganisms producing metabolites that affect the flavor or nutritive value of foods. Included in the section dealing with fermented foods are procedures for the maintenance of lactic acid bacteria, the isolation of plasmid and genomic DNA from species Lactobacillus, and the determination of proteolytic activity of lactic acid bacteria. A substantial number of chapters are devoted to yeasts, their use in food and beverage production, and techniques for improving industrially important strains. Comprehensive and timely, Food Microbiology Protocols is a gold-standard collection of readily reproducible techniques essential for the study of the wide variety of microorganisms involved in food production, quality, storage, and preservation today.

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RNA Modification

RNA Modification, Volume 425 (Methods in Enzymology)
by Jonatha Gott (Editor)

Product Details:
* Hardcover: 480 pages
* Publisher: Academic Press; 1 edition (August 6, 2007)
* Language: English
* ISBN-10: 0123741556

Book Description
The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers.

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Virus Structure

Virus Structure, Volume 64 (Advances in Protein Chemistry)
by Wah Chiu (Editor), John Johnson (Editor)

Product Details:
* Hardcover: 543 pages
* Publisher: Academic Press (August 25, 2003)
* Language: English
* ISBN-10: 0120342642

Book Description:
This volume covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses.
* Covers viral assembly using heterologous expression systems and cell extracts
* Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment
* Includes information on structural studies on antibody/virus complexes.

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Cytokines and the CNS

Cytokines and the CNS, Second Edition
by Richard M. Ransohoff (Editor), Etty N. Benveniste (Editor)

Product Details:
* Hardcover: 384 pages
* Publisher: CRC; 2 edition (October 31, 2005)
* Language: English
* ISBN-10: 0849316227

Book Description
As with the first edition of Cytokines and the CNS, this completely updated and revised edition introduces neurobiologists to cytokine biology and immunologists to the unique functions of cytokines in CNS physiology. The dramatically accelerating interest in cytokines and cytokine/chemokine signaling over the past several years has encouraged an explosion of literature on cytokines. The similarity between factors involved in inflammation or immunity, and those implicated in neural development, physiology, and repair has become so apparent that familiarity with cytokines must now be considered an essential element in the neurobiologist's cognitive tool-kit. Conversely, for immunobiologists, the concepts elaborated by neurobiologists to understand developmental patterning and networked organ function continue to evolve in such a way that comprehension of cytokine action in the CNS can only enhance a further understanding of immune system function. Cytokines and the CNS, Second Edition is patterned after the first edition; however, the wealth of knowledge now available adds a tremendous amount of insight and new implications. To guarantee a fresh perspective, the editors made a conscious choice to utilize an entirely new set of contributors, all experts in various aspects of cytokine research. Cytokines and the CNS, Second Edition starts with a chapter on the CNS, focusing on pathological reactions to insult. Next, come three chapters on cytokine biology, followed by four chapters that integrate cytokine biology into basic CNS processes (development; inflammation; immunity; degeneration/repair), after which five chapters apply this body of knowledge to disease or pathology. The book closes with a look at the application of cytokine biology to the treatment of disease, a brand new area of research.

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MRSA

MRSA
by John A. Weigelt (Editor)

Product Details:
* Paperback: 232 pages
* Publisher: Informa Healthcare (November 20, 2006)
* Language: English
* ISBN-10: 1420045490

Book Description
Responding to the growing concern about the increased frequency and resistance of MRSA infections, this invaluable source analyzes the latest developments in the identification, assessment, and management of methicillin-resistant Staphylococcus aureus (MRSA) by leading authorities on the topic.

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Regulatory RNAs

Regulatory RNAs
by Bruce Stillman (Editor), David Stewart (Editor)

Product Details:
* Paperback: 550 pages
* Publisher: Cold Spring Harbor Laboratory Press; 1 edition (June 30, 2007)
* Language: English
* ISBN-10: 0879698187

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MicroRNA Methods

MicroRNA Methods, Volume 427 (Methods in Enzymology)
by John J. Rossi (Editor)

Product Details:
* Hardcover: 304 pages
* Publisher: Academic Press; 1 edition (September 4, 2007)
* Language: English
* ISBN-10: 0123739179

Book Description
MicroRNAs (miRNA) are tiny bits of genetic material that were unknown nearly 10 years ago but now represent an exciting field of study in biology. Upon their discovery, researchers revealed for the first time a new mechanism by which microRNA can stop the function of messenger RNA (mRNA) by literally cutting it in half, interfering with the normal function of specific messenger RNAs in gene expression.
This "expression" of genes that code for essential proteins is essentially what controls whether a cell turns into a liver, lung, or brain cell, for example. Understanding what activates this process or stops it is a key to understanding the biological process and builds a foundation for advances in medicine and other fields. This volume in Methods in Enzymology presents valuable methods for studying MicroRNA, with three sections covering identification of MicroRNAs and their targets; Micro RNA expression, maturation and functional analysis; and MicroRNAs and disease.

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Immune Mediated Diseases: From Theory to Therapy

Immune Mediated Diseases: From Theory to Therapy (Advances in Experimental Medicine and Biology)
by Michael R. Shurin (Editor), Yuri S. Smolkin (Editor)

Product Details:
* Hardcover: 458 pages
* Publisher: Springer; 1 edition (July 25, 2007)
* Language: English
* ISBN-10: 0387720049

Book Description
The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the best world immunologists and clinicians to Moscow to participate in plenary sessions, symposia and educational workshops designed to expose basic and clinical immunologist as well as practicing clinicians to the newest developments in the field. First IMD Congress consisted of 8 Plenary Sessions, 40 Symposia and 25 Workshops. The meeting attracted almost 2000 participants and speakers from 15 countries. After this great success of the First IMD Congress, the Organizing Committee decided to convene the meeting every other year and the Second International IMD Congress was planned for September 2007. Special attention will be given to innovative therapeutic modalities, allergy and asthma, immunodeficiency, tumor and transplant immunology, immunotherapy and vaccines, HIV and infectious diseases, autoimmune diseases, inflammation, immunomonitoring and immunodiagnostics.

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Vaccinia Virus and Poxvirology: Methods and Protocols

Vaccinia Virus and Poxvirology: Methods and Protocols
by Stuart N. Isaacs (Editor)

Product Details:
* Hardcover: 416 pages
* Publisher: Humana Press; 1 edition (April 19, 2004)
* Language: English
* ISBN-10: 1588292290

Book Description
A comprehensive collection of cutting-edge methods to study and work with the vaccinia virus and other poxvirus gene transcriptions. These readily reproducible techniques can be used for the construction and characterization of recombinant viruses; for the study of poxvirus gene transcription and DNA replication; for the investigation of the binding, entry, and movement of the virus in host cells; and for the use of the virus in immunologic and cell-cell fusion assays. Other methods cover poxvirus bioinformatics, aspects of viral pathogenesis at both a protein and an animal model level, and the study of immune responses to poxviruses-the latter a critical ability given the important role of vaccinia virus in smallpox vaccination and their potential role as vaccine vectors directed against infectious agents and cancer.

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Sterile Filtration: A Practical Approach

Sterile Filtration: A Practical Approach
by Maik W. Jornitz (Author), Theodore H. Meltzer (Author)

Product Details:
* Hardcover: 623 pages
* Publisher: Informa Healthcare; 1st edition (January 15, 2001)
* Language: English
* ISBN-10: 0824702824

Book Description
This book focuses on sterilizing grade filters in the biopharmaceutical industry, emphasizing practical applications of universal and dependable operational protocols, integrity testing, and troubleshooting to streamline the production and preparation of pharmaceuticals. Addresses the complexities of globalizing redundancy in filtration! Enabling educated developmental, procedural, and regulatory judgments to be made in the manufacturing of sterile health care products, Sterile Filtration · considers how many filters should be in the process stream · examines the existence of nanobacteria and viable but nonculturable organisms · covers pore size designations, distributions, architecture, and numbers · discusses the latest findings in bubble point and diffuse flow measurements · describes pre- and postfiltration, up- and downstream testing, and after-stream sterilizations · details wetting liquid, polymer, temperature, and water purity effects · explains sieve retention, size exclusion, adsorptive sequestrations, charge-related phenomena, gravitational settling, and interference factors in liquids and gases · outlines filter validation, requirements, and operational specifics · and more! Advocating separation in addition to physical destruction of microorganisms, Sterile Filtration is a reference essential for pharmaceutical scientists; biotechnologists; microbiologists; virologists; process and chemical engineers; plant, production, validation, and quality control managers in the pharmaceutical and biotechnology industries; and upper-level undergraduate and graduate school students in these disciplines.

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Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas

Handbook of Immunohistochemistry and in situ Hybridization of Human Carcinomas : Molecular Genetics: Liver and Pancreatic Carcinomas
by M. A. Hayat (Editor)

Product Details:
* Hardcover: 480 pages
* Publisher: Academic Press (August 31, 2005)
* Language: English
* ISBN-10: 0120884046

Book Description
Immunohistochemistry is the use of specific antibodies to stain particular molecular species in situ. This technique has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system, and has the potential to improve diagnosis, prognosis and therapeutic options of cancer.
This book discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today.

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Imaging of Pulmonary Infections: A Fundamental and Clinical Text

Imaging of Pulmonary Infections: A Fundamental and Clinical Text
by Nestor L Müller (Author), Tomás Franquet (Author), Kyung Soo Lee (Author), C. IsabelaS Silva (Author)

Product Details:
* Hardcover: 184 pages
* Publisher: Lippincott Williams & Wilkins; 3 edition (August 1, 2006)
* Language: English
* ISBN-10: 078177232X

Book Description
This book presents a practical approach to the differential diagnosis of pulmonary infections based on their radiographic and CT appearances. The authors discuss the value and limitations of chest radiography, the indications for CT, the optimal CT techniques, and the role of intravenous contrast. Chapters describe and illustrate the characteristic imaging manifestations of common community-acquired and nosocomial pneumonias and various infections seen in immunocompromised patients. The book contains over 400 images and many tables that summarize the characteristic manifestations of bacterial, mycobacterial, fungal, and viral infections. Over 50 full-color illustrations show histopathologic or microbiologic features that correlate with imaging findings.

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